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hnf4b hepatic nuclear factor 4, beta [ Danio rerio (zebrafish) ]

Gene ID: 324010, updated on 9-Dec-2024

Summary

Official Symbol
hnf4bprovided by ZNC
Official Full Name
hepatic nuclear factor 4, betaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2730
See related
AllianceGenome:ZFIN:ZDB-GENE-030131-2730
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc16g07; zgc:77387; wu:fc16g07
Summary
Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in yolk syncytial layer. [provided by Alliance of Genome Resources, Dec 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
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Genomic context

See hnf4b in Genome Data Viewer
Location:
chromosome: 7
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (69019595..69047681)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (68795418..68811076)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_008805355.1 (1141..1511)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene polyamine modulated factor 1 binding protein 1 Neighboring gene zinc finger homeobox 3b Neighboring gene uncharacterized LOC137496239 Neighboring gene hepatocyte nuclear factor 4-gamma-like Neighboring gene cysteine-rich secretory protein LCCL domain containing 2 Neighboring gene ubiquitin specific peptidase 10

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hepatic nuclear factor 4, beta
Names
NR2A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205546.1NP_991109.1  hepatic nuclear factor 4, beta

    See identical proteins and their annotated locations for NP_991109.1

    Status: PROVISIONAL

    Source sequence(s)
    BC065657
    UniProtKB/TrEMBL
    Q6P0E0
    Conserved Domains (2) summary
    cd06931
    Location:153368
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:63138
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    69019595..69047681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)