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dpr8 defective proboscis extension response 8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32387, updated on 9-Dec-2024

Summary

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Official Symbol
dpr8provided by FlyBase
Official Full Name
defective proboscis extension response 8provided by FlyBase
Primary source
FLYBASE:FBgn0052600
Locus tag
Dmel_CG32600
See related
AllianceGenome:FB:FBgn0052600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11477; CG14415; CG32600; CG5291; CT16867; Dmel\CG32600; dpr 8; Dpr-8; Dpr8
Summary
Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See dpr8 in Genome Data Viewer
Location:
12E8-12E10; 1-48 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14322226..14462351)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14216259..14356384)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Nascent-associated complex beta-subunit-like, testis 2 Neighboring gene Nascent-associated complex beta-subunit-like, testis 6 Neighboring gene Nascent-associated complex beta-subunit-like, testis 3 Neighboring gene Nascent-associated complex beta-subunit-like, testis 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-Affinity Sites Form an Interaction Network to Facilitate Spreading of the MSL Complex across the X Chromosome in Drosophila. Ramírez F, et al. Mol Cell, 2015 Oct 1. PMID 26431028, Free PMC Article
  2. Population genetic evidence for cold adaptation in European Drosophila melanogaster populations. Božičević V, et al. Mol Ecol, 2016 Mar. PMID 26558479
  3. The dosage compensation complex shapes the conformation of the X chromosome in Drosophila. Grimaud C, et al. Genes Dev, 2009 Nov 1. PMID 19884256, Free PMC Article
  4. Transneuronal Dpr12/DIP-δ interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons. Bornstein B, et al. EMBO J, 2021 Jun 15. PMID 33847376, Free PMC Article
  5. Classifying Protein-Protein Binding Affinity with Free-Energy Calculations and Machine Learning Approaches. Goulard Coderc de Lacam E, et al. J Chem Inf Model, 2024 Feb 12. PMID 38272021

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in sensory perception of chemical stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synapse organization IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in neuron projection membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
defective proboscis extension response 8
Names
CG32600-PA
CG32600-PB
dpr8-PA
dpr8-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    14322226..14462351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167408.2 → NP_727781.1  defective proboscis extension response 8, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727781.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SR2, Q9VY33
    Related
    FBpp0073730
    Conserved Domains (3) summary
    smart00410
    Location:153 → 238
    IG_like; Immunoglobulin like
    pfam00047
    Location:153 → 232
    ig; Immunoglobulin domain
    pfam07686
    Location:52 → 143
    V-set; Immunoglobulin V-set domain

  2. NM_001298310.1 → NP_001285239.1  defective proboscis extension response 8, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285239.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SR2, Q9VY33
    Conserved Domains (3) summary
    smart00410
    Location:153 → 238
    IG_like; Immunoglobulin like
    pfam00047
    Location:153 → 232
    ig; Immunoglobulin domain
    pfam07686
    Location:52 → 143
    V-set; Immunoglobulin V-set domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95T89 Q95T89
Q9VY33 Q9VY33

Gene LinkOut

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