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Dus2 Dihydrouridine synthase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32377, updated on 9-Dec-2024

Summary

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Official Symbol
Dus2provided by FlyBase
Official Full Name
Dihydrouridine synthase 2provided by FlyBase
Primary source
FLYBASE:FBgn0030554
Locus tag
Dmel_CG1434
See related
AllianceGenome:FB:FBgn0030554
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1434; Dmel\CG1434
Summary
Predicted to enable tRNA-dihydrouridine20 synthase activity. Predicted to be involved in tRNA dihydrouridine synthesis. Predicted to be active in cytoplasm. Is expressed in several structures, including anlage in statu nascendi; antennal primordium; ganglia; gut section; and head epidermis primordium. Orthologous to human DUS2 (dihydrouridine synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Dus2 in Genome Data Viewer
Location:
12E5-12E5; 1-48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14237988..14240152)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14132021..14134185)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene F box and leucine-rich-repeat gene 4 Neighboring gene mRNA-capping-enzyme Neighboring gene antisense RNA:CR46473 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular evolution of dihydrouridine synthases. Kasprzak JM, et al. BMC Bioinformatics, 2012 Jun 28. PMID 22741570, Free PMC Article
  2. Control of Cell Growth and Proliferation by the Tribbles Pseudokinase: Lessons from Drosophila. Dobens LL, et al. Cancers (Basel), 2021 Feb 20. PMID 33672471, Free PMC Article
  3. H/ACA snRNP-dependent ribosome biogenesis regulates translation of polyglutamine proteins. Breznak SM, et al. Sci Adv, 2023 Jun 23. PMID 37343092, Free PMC Article
  4. Chronic low-dose γ-irradiation of Drosophila melanogaster larvae induces gene expression changes and enhances locomotive behavior. Kim CS, et al. J Radiat Res, 2015 May. PMID 25792464, Free PMC Article
  5. A high-throughput pipeline for the production of synthetic antibodies for analysis of ribonucleoprotein complexes. Na H, et al. RNA, 2016 Apr. PMID 26847261, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA dihydrouridine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-dihydrouridine20 synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in tRNA dihydrouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dihydrouridine synthase 2
Names
CG1434-PA
CG1434-PB
Dus2-PA
Dus2-PB
NP_001285237.1
NP_572950.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    14237988..14240152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298308.1 → NP_001285237.1  dihydrouridine synthase 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285237.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K0H3, Q9VY45
    Conserved Domains (4) summary
    COG0042
    Location:14 → 287
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    COG0571
    Location:317 → 461
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00048
    Location:395 → 457
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd02801
    Location:25 → 266
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

  2. NM_132722.3 → NP_572950.2  dihydrouridine synthase 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572950.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K0H3, Q9VY45
    Related
    FBpp0073720
    Conserved Domains (4) summary
    COG0042
    Location:14 → 287
    DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
    COG0571
    Location:317 → 461
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00048
    Location:395 → 457
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd02801
    Location:25 → 266
    DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K0H3 Q7K0H3
Q9VY45 Q9VY45

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