U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

vapb VAMP (vesicle-associated membrane protein)-associated protein B and C [ Danio rerio (zebrafish) ]

Gene ID: 323628, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
vapbprovided by ZNC
Official Full Name
VAMP (vesicle-associated membrane protein)-associated protein B and Cprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2348
See related
Ensembl:ENSDARG00000070435 AllianceGenome:ZFIN:ZDB-GENE-030131-2348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc05d09; zgc:66045; wu:fa96d05; wu:fc05d09
Summary
Predicted to enable protein-membrane adaptor activity. Acts upstream of or within regulation of heart contraction and swimming behavior. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Is expressed in atrium; cardiac ventricle; and heart. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human VAPB (VAMP associated protein B and C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See vapb in Genome Data Viewer
Location:
chromosome: 6
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (49583151..49638688)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (49584570..49653214)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 4, regulatory subunit 1-like Neighboring gene RAB22A, member RAS oncogene family Neighboring gene adenomatosis polyposis coli down-regulated 1-like Neighboring gene syntaxin 16

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ALS-Linked VapB P56S Mutation Alters Neuronal Mitochondrial Turnover at the Synapse. Wong HC, et al. J Neurosci, 2024 Aug 28. PMID 39054069,
  2. The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. Silbernagel N, et al. FASEB J, 2018 Nov. PMID 29879376, Free PMC Article
  3. Investigating the contribution of VAPB/ALS8 loss of function in amyotrophic lateral sclerosis. Kabashi E, et al. Hum Mol Genet, 2013 Jun 15. PMID 23446633
  4. Translation repression by maternal RNA binding protein Zar1 is essential for early oogenesis in zebrafish. Miao L, et al. Development, 2017 Jan 1. PMID 27913641
  5. A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery. Tiefenbach J, et al. PLoS One, 2010 Mar 22. PMID 20339547, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ALS-Linked VapB P56S Mutation Alters Neuronal Mitochondrial Turnover at the Synapse.
    Title: ALS-Linked VapB P56S Mutation Alters Neuronal Mitochondrial Turnover at the Synapse.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein-membrane adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum-plasma membrane tethering IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of heart contraction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within swimming behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
vesicle-associated membrane protein-associated protein B/C
Names
vesicle-associated membrane protein, associated protein B and C

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212647.2 → NP_997812.1  vesicle-associated membrane protein-associated protein B/C

    See identical proteins and their annotated locations for NP_997812.1

    Status: VALIDATED

    Source sequence(s)
    BX323459, EH552051
    UniProtKB/TrEMBL
    A0A2R8QTI7, F6NWL2, Q6P2B0
    Related
    ENSDARP00000094134.4, ENSDART00000103357.5
    Conserved Domains (1) summary
    pfam00635
    Location:8 → 111
    Motile_Sperm; MSP (Major sperm protein) domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    49583151..49638688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476783.2 → XP_021332458.1  vesicle-associated membrane protein-associated protein B/C isoform X1

    UniProtKB/TrEMBL
    A0A8M9PZG9
    Conserved Domains (1) summary
    pfam00635
    Location:8 → 111
    Motile_Sperm; MSP (Major sperm protein) domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394670.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    41904..94028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.