ewsr1a EWS RNA-binding protein 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ewsr1aprovided by ZNC
Official Full Name: EWS RNA-binding protein 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2317
See related: Ensembl:ENSDARG00000020258 AllianceGenome:ZFIN:ZDB-GENE-030131-2317
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: EWSR1; fc04c01; wu:fc04c01
Summary: Enables chromatin binding activity. Acts upstream of or within several processes, including mitotic spindle midzone assembly; regulation of chondrocyte hypertrophy; and regulation of mitotic nuclear division. Predicted to be active in nucleus. Is expressed in fin bud; nervous system; and trunk. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (7975585..7988412, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (8016885..8029728, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutation of the EWS gene modulates Sox9 gene expression essential for chondrocyte differentiation.
Title: Ewing sarcoma ewsa protein regulates chondrogenesis of Meckel's cartilage through modulation of Sox9 in zebrafish.
Interaction between EWSR1/FLI1 and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
Title: Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines.
Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development
Title: Ewing sarcoma protein ewsr1 maintains mitotic integrity and proneural cell survival in the zebrafish embryo.

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General gene information

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Markers

fb23d12.y1 (e-PCR)
- UniSTS:190323

fc04c01.x1 (e-PCR)
- UniSTS:203692

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within central nervous system neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic spindle midzone assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of chondrocyte hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: EWS RNA-binding protein 1a

Names: Ewing sarcoma breakpoint region 1; Ewing sarcoma breakpoint region 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001115138.2 → NP_001108610.1 EWS RNA-binding protein 1a

See identical proteins and their annotated locations for NP_001108610.1

Status: VALIDATED

Source sequence(s)

BC068397, CN835703, DT075886, EH467947, FP131351, FP154885

UniProtKB/TrEMBL

A0A0B4J1A5, A0A8N1TRE3, Q6NUX1

Related

ENSDARP00000024102.7, ENSDART00000024282.9

Conserved Domains (4) summary

COG0724
Location:329 → 431

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12533
Location:346 → 429

RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)

sd00025
Location:499 → 520

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam00641
Location:495 → 525

zf-RanBP; Zn-finger in Ran binding protein and others

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

7975585..7988412 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479109.2 → XP_021334784.1 EWS RNA-binding protein 1a isoform X1

UniProtKB/TrEMBL

A0A8M9QBU8, Q6NUX1

Conserved Domains (3) summary

cd12533
Location:317 → 400

RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)

sd00025
Location:470 → 491

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam00641
Location:466 → 496

zf-RanBP; Zn-finger in Ran binding protein and others