cltca clathrin, heavy chain a (Hc) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cltcaprovided by ZNC
Official Full Name: clathrin, heavy chain a (Hc)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2299
See related: Ensembl:ENSDARG00000043493 AllianceGenome:ZFIN:ZDB-GENE-030131-2299
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cltc; cb1033; wu:fc03e11; wu:fc49a11; wu:fd07f02
Summary: Predicted to enable clathrin light chain binding activity and structural molecule activity. Predicted to be involved in intracellular protein transport. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in clathrin-coated pit and cytoplasmic vesicle. Predicted to be part of clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; and clathrin complex. Is expressed in axial vasculature; blood; intermediate cell mass of mesoderm; notochord; and ventral mesoderm. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 56. Orthologous to human CLTC (clathrin heavy chain). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (28311016..28368972, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (28424391..28482353, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb79f10.x1 (e-PCR)
- UniSTS:191504

fb79f10.x1 (e-PCR)
- UniSTS:191505

fd03h09.y1 (e-PCR)
- UniSTS:194898

fc03e11.x1 (e-PCR)
- UniSTS:192121

fc90a05.y1 (e-PCR)
- UniSTS:194773

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables clathrin light chain binding	IEA Inferred from Electronic Annotation more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of clathrin coat of coated pit	IEA Inferred from Electronic Annotation more info
part_of clathrin coat of trans-Golgi network vesicle	IEA Inferred from Electronic Annotation more info
part_of clathrin complex	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: clathrin, heavy chain a (Hc)

Names: clathrin, heavy polypeptide a (Hc)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005391.2 → NP_001005391.2 clathrin, heavy chain a (Hc)

Status: VALIDATED

Source sequence(s)

AY648777, BC163714, CR392341, EB769086

UniProtKB/TrEMBL

A0A8M1N2E2, A0A8M2BJY0, B3DK43, F1R966

Related

ENSDARP00000063848.4, ENSDART00000063849.5

Conserved Domains (5) summary

smart00299
Location:1274 → 1416

CLH; Clathrin heavy chain repeat homology

pfam00637
Location:1427 → 1564

Clathrin; Region in Clathrin and VPS

pfam01394
Location:198 → 234

Clathrin_propel; Clathrin propeller repeat

pfam09268
Location:331 → 353

Clathrin-link; Clathrin, heavy-chain linker

pfam13838
Location:364 → 421

Clathrin_H_link; Clathrin-H-link