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inaE inactivation no afterpotential E [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32343, updated on 9-Dec-2024

Summary

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Official Symbol
inaEprovided by FlyBase
Official Full Name
inactivation no afterpotential Eprovided by FlyBase
Primary source
FLYBASE:FBgn0261244
Locus tag
Dmel_CG33174
See related
AllianceGenome:FB:FBgn0261244
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11096; CG11102; CG11104; CG15761; CG32630; CG33174; DAGL; DAGL/inaE; dDAGL; Dmel\CG33174; EP(X)1101; INAE
Summary
Enables lipoprotein lipase activity. Involved in phototransduction and response to oxidative stress. Located in cytoplasm. Is expressed in several structures, including adult head; calyx of adult mushroom body; embryonic dorsal epidermis; embryonic head epidermis; and ganglia. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human DAGLA (diacylglycerol lipase alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See inaE in Genome Data Viewer
Location:
12C4-12C5; 1-46 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13783714..13811493)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13677747..13705526)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Cathepsin B Neighboring gene amaretto Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Chloride intracellular channel

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Endocannabinoids produced in photoreceptor cells in response to light activate Drosophila TRP channels. Sokabe T, et al. Sci Signal, 2022 Oct 11. PMID 36219683, Free PMC Article
  2. Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB(1) Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogaster. Tortoriello G, et al. Cannabis Cannabinoid Res, 2021 Apr. PMID 33912677, Free PMC Article
  3. Lipid Hydrolase Enzymes: Pragmatic Prolongevity Targets for Improved Human Healthspan? Johnson AA. Rejuvenation Res, 2020 Apr. PMID 31426688
  4. DAG lipase activity is necessary for TRP channel regulation in Drosophila photoreceptors. Leung HT, et al. Neuron, 2008 Jun 26. PMID 18579079, Free PMC Article
  5. Feeling the hidden mechanical forces in lipid bilayer is an original sense. Anishkin A, et al. Proc Natl Acad Sci U S A, 2014 Jun 3. PMID 24850861, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lipoprotein lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipoprotein lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in arachidonate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in diacylglycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phototransduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
inactivation no afterpotential E
Names
CG33174-PA
CG33174-PD
CG33174-PE
CG33174-PF
CG33174-PG
CG33174-PH
CG33174-PI
diacylglycerol lipase
inaE-PA
inaE-PD
inaE-PE
inaE-PF
inaE-PG
inaE-PH
inaE-PI
NP_001138195.1
NP_001138196.1
NP_001285230.1
NP_001285231.1
NP_001401060.1
NP_788900.1
NP_788901.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13783714..13811493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144724.2 → NP_001138196.1  inactivation no afterpotential E, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138196.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z151
    Conserved Domains (1) summary
    cd00519
    Location:300 → 542
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...

  2. NM_001144723.2 → NP_001138195.1  inactivation no afterpotential E, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138195.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z150
    Conserved Domains (1) summary
    cd00519
    Location:300 → 542
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...

  3. NM_001298302.1 → NP_001285231.1  inactivation no afterpotential E, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285231.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JDP4
    Conserved Domains (1) summary
    cd00519
    Location:300 → 542
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...

  4. NM_001298301.1 → NP_001285230.1  inactivation no afterpotential E, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285230.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JBS2
    Conserved Domains (1) summary
    cd00519
    Location:300 → 542
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...

  5. NM_176727.3 → NP_788900.1  inactivation no afterpotential E, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788900.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86B55
    Related
    FBpp0073656
    Conserved Domains (1) summary
    cd00519
    Location:300 → 542
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...

  6. NM_176728.3 → NP_788901.1  inactivation no afterpotential E, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788901.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MR12
    Related
    FBpp0073657
    Conserved Domains (1) summary
    cd00519
    Location:300 → 542
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...

  7. NM_001414079.1 → NP_001401060.1  inactivation no afterpotential E, isoform I [Drosophila melanogaster]

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z150 B7Z150
B7Z151 B7Z151
Q86B55 Q86B55
Q8MR12 Q8MR12
Q8MR52 Q8MR52
X2JBS2 X2JBS2
X2JDP4 X2JDP4

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