Yp3 Yolk protein 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Yp3provided by FlyBase
Official Full Name: Yolk protein 3provided by FlyBase
Primary source: FLYBASE:FBgn0004047
Locus tag: Dmel_CG11129
See related: AllianceGenome:FB:FBgn0004047
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11129; DIM 30; Dmel\CG11129; fs(1)1526; fs(1)A1526; RH08557p; VG3; VIT3Dm; yp; YP; YP-3; yp3; YP3; YP[[3]]
Summary: Enables serine hydrolase activity. Involved in embryo development and regulation of embryonic development. Located in P granule and extracellular region. Is expressed in several structures, including adult head; adult heart; centripetal follicle cell; egg chamber; and epithelium. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13759546..13761547)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13653579..13655580)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The expression of all YP1, YP2 and YP3 genes was shown to be a unique feature of testis tissues.
Title: Yolk proteins in the male reproductive system of the fruit fly Drosophila melanogaster: spatial and temporal patterns of expression.
Yp (Yolk protein) expression is significantly negatively correlated with longevity, an important life history trait, for both males and females.
Title: Genetic variation in the Yolk protein expression network of Drosophila melanogaster: sex-biased negative correlations with longevity.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
NOT enables lipase activity	IKR Inferred from Key Residues more info	PubMed
enables serine hydrolase activity	HDA more info	PubMed

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to bacterium	HEP more info	PubMed
involved_in sex differentiation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in P granule	IPI Inferred from Physical Interaction more info	PubMed
located_in extracellular region	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

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