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sin3ab SIN3 transcription regulator family member Ab [ Danio rerio (zebrafish) ]

Gene ID: 323346, updated on 9-Dec-2024

Summary

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Official Symbol
sin3abprovided by ZNC
Official Full Name
SIN3 transcription regulator family member Abprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2066
See related
Ensembl:ENSDARG00000059812 AllianceGenome:ZFIN:ZDB-GENE-030131-2066
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb95g11; wu:fb95g11
Summary
Predicted to enable transcription corepressor activity. Acts upstream of or within heart development. Predicted to be located in chromatin. Predicted to be part of Sin3-type complex. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See sin3ab in Genome Data Viewer
Location:
chromosome: 7
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (48347290..48396207, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (48074498..48123465, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 44b Neighboring gene cellular retinoic acid binding protein 1b Neighboring gene leucine rich repeat and Ig domain containing 1b Neighboring gene potassium voltage-gated channel, KQT-like subfamily, member 1.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish sin3b mutants are viable but have size, skeletal, and locomotor defects. Moravec CE, et al. Dev Dyn, 2017 Nov. PMID 28850761, Free PMC Article
  2. Sin3a associated protein 130 kDa, sap130, plays an evolutionary conserved role in zebrafish heart development. DeMoya RA, et al. Front Cell Dev Biol, 2023. PMID 37711853, Free PMC Article
  3. Zebrafish rest regulates developmental gene expression but not neurogenesis. Kok FO, et al. Development, 2012 Oct. PMID 22951640, Free PMC Article
  4. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SIN3 transcription regulator family member Ab; paired amphipathic helix protein Sin3a
Names
SIN3 homolog A, transcription regulator b

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    48347290..48396207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002662877.7 → XP_002662923.1  paired amphipathic helix protein Sin3a isoform X2

    UniProtKB/TrEMBL
    A0A8M1RR38, E7F0R9
    Related
    ENSDARP00000077990.5, ENSDART00000083555.7
    Conserved Domains (4) summary
    COG5602
    Location:110 → 1211
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:136 → 180
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:548 → 642
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:880 → 1178
    Sin3a_C; C-terminal domain of Sin3a protein

  2. XM_009303423.4 → XP_009301698.1  paired amphipathic helix protein Sin3a isoform X1

    UniProtKB/TrEMBL
    A0A8M3B4C3
    Conserved Domains (4) summary
    COG5602
    Location:110 → 1218
    Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
    pfam02671
    Location:136 → 180
    PAH; Paired amphipathic helix repeat
    pfam08295
    Location:555 → 649
    Sin3_corepress; Sin3 family co-repressor
    pfam16879
    Location:887 → 1185
    Sin3a_C; C-terminal domain of Sin3a protein
Nucleotide Protein Strain
Heading Accession and Version

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