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snx4 sorting nexin 4 [ Danio rerio (zebrafish) ]

Gene ID: 323203, updated on 4-Jan-2025

Summary

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Official Symbol
snx4provided by ZNC
Official Full Name
sorting nexin 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1923
See related
Ensembl:ENSDARG00000022659 AllianceGenome:ZFIN:ZDB-GENE-030131-1923
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:6971267; wu:fb92d09; zgc:113437
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in positive regulation of autophagosome assembly and protein transport. Predicted to be part of SNARE complex. Predicted to be active in early endosome membrane and plasma membrane. Is expressed in notochord. Orthologous to human SNX4 (sorting nexin 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See snx4 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (38588091..38621202)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (38778296..38811407)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 11 Neighboring gene transforming growth factor beta receptor-like Neighboring gene zinc finger protein 148 Neighboring gene solute carrier family 12 member 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish. Xu L, et al. Hepatology, 2012 Jun. PMID 22213104
  2. A comparative map of the zebrafish genome. Woods IG, et al. Genome Res, 2000 Dec. PMID 11116086, Free PMC Article
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sorting nexin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014346.1 → NP_001014368.1  sorting nexin-4

    See identical proteins and their annotated locations for NP_001014368.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091982
    UniProtKB/TrEMBL
    Q58EC1
    Related
    ENSDARP00000033122.4, ENSDART00000031127.6
    Conserved Domains (2) summary
    cd06864
    Location:41 → 168
    PX_SNX4; The phosphoinositide binding Phox Homology domain of Sorting Nexin 4
    cd07622
    Location:189 → 432
    BAR_SNX4; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 4

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    38588091..38621202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223291.1 → XP_068079392.1  sorting nexin-4 isoform X1

  2. XM_068223292.1 → XP_068079393.1  sorting nexin-4 isoform X2

  3. XM_068223293.1 → XP_068079394.1  sorting nexin-4 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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