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Tpst Tyrosylprotein sulfotransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32312, updated on 14-Nov-2024

Summary

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Official Symbol
Tpstprovided by FlyBase
Official Full Name
Tyrosylprotein sulfotransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0086674
Locus tag
Dmel_CG32632
See related
AllianceGenome:FB:FBgn0086674
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1573; CG15758; CG15759; CG32629; CG32629/CG32632; CG32632; Dmel\CG32632; DmTPST; Tango13; TANGO13; TPST
Old locus tag
CG15758; CG32629; Dmel_CG15758; Dmel_CG32629
Summary
Enables protein-tyrosine sulfotransferase activity. Involved in protein secretion. Located in Golgi apparatus. Is expressed in adult head. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human TPST1 (tyrosylprotein sulfotransferase 1) and TPST2 (tyrosylprotein sulfotransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Tpst in Genome Data Viewer
Location:
12A4-12A7; 1-44 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13563823..13593224)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13457856..13487257)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene upheld Neighboring gene long non-coding RNA:CR44654

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fluorescence assay for protein post-translational tyrosine sulfation. Chen BH, et al. Anal Bioanal Chem, 2013 Feb. PMID 23161068
  2. High-Throughput Screening of Sulfated Proteins by Using a Genome-Wide Proteome Microarray and Protein Tyrosine Sulfation System. Huang BY, et al. Anal Chem, 2017 Mar 21. PMID 28211678
  3. Preparation of Tyrosylprotein Sulfotransferases for In Vitro One-Pot Enzymatic Synthesis of Sulfated Proteins/Peptides. Wang CC, et al. ACS Omega, 2018 Sep 30. PMID 30320268, Free PMC Article
  4. Sxl-Dependent, tra/tra2-Independent Alternative Splicing of the Drosophila melanogaster X-Linked Gene found in neurons. Sun X, et al. G3 (Bethesda), 2015 Oct 28. PMID 26511498, Free PMC Article
  5. Design of RNA splicing analysis null models for post hoc filtering of Drosophila head RNA-Seq data with the splicing analysis kit (Spanki). Sturgill D, et al. BMC Bioinformatics, 2013 Nov 9. PMID 24209455, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-tyrosine sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-tyrosine sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-tyrosine sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-tyrosine sulfation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tyrosylprotein sulfotransferase
Names
CG32632-PB
CG32632-PC
CG32632-PD
CG32632-PE
CG32632-PF
CG32632-PG
Tpst-PB
Tpst-PC
Tpst-PD
Tpst-PE
Tpst-PF
Tpst-PG
transport and golgi organization
transport and golgi organization 13
NP_001096973.1
NP_001259518.1
NP_001259519.1
NP_001259520.1
NP_001259521.1
NP_727717.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13563823..13593224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272591.1 → NP_001259520.1  tyrosylprotein sulfotransferase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259520.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q58CJ7, Q8MM59, Q9VYB7
    UniProtKB/TrEMBL
    M9PEH9
    Conserved Domains (1) summary
    pfam13469
    Location:73 → 264
    Sulfotransfer_3; Sulfotransferase family

  2. NM_001272592.1 → NP_001259521.1  tyrosylprotein sulfotransferase, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259521.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JUV2
    Conserved Domains (1) summary
    pfam13469
    Location:70 → 258
    Sulfotransfer_3; Sulfotransferase family

  3. NM_001272590.1 → NP_001259519.1  tyrosylprotein sulfotransferase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259519.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JUV2
    Conserved Domains (1) summary
    pfam13469
    Location:70 → 258
    Sulfotransfer_3; Sulfotransferase family

  4. NM_001103503.2 → NP_001096973.1  tyrosylprotein sulfotransferase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096973.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JUV2
    Conserved Domains (1) summary
    pfam13469
    Location:70 → 258
    Sulfotransfer_3; Sulfotransferase family

  5. NM_167374.3 → NP_727717.1  tyrosylprotein sulfotransferase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727717.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q58CJ7, Q8MM59, Q9VYB7
    UniProtKB/TrEMBL
    M9PEH9
    Related
    FBpp0290842
    Conserved Domains (1) summary
    pfam13469
    Location:73 → 264
    Sulfotransfer_3; Sulfotransferase family

  6. NM_001272589.1 → NP_001259518.1  tyrosylprotein sulfotransferase, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259518.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHI3
    Conserved Domains (1) summary
    pfam13469
    Location:70 → 258
    Sulfotransfer_3; Sulfotransferase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JUV2 A8JUV2
M9PEH9 M9PEH9
M9PHI3 M9PHI3
Q9VYB7.2 Q9VYB7

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