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Syt12 Synaptotagmin 12 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32290, updated on 4-Jan-2025

Summary

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Official Symbol
Syt12provided by FlyBase
Official Full Name
Synaptotagmin 12provided by FlyBase
Primary source
FLYBASE:FBgn0261085
Locus tag
Dmel_CG10617
See related
AllianceGenome:FB:FBgn0261085
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10617; Dmel\CG10617; dsyt12; Syt 12; syt-12; syt12; SYT12
Summary
Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in regulation of calcium ion-dependent exocytosis and vesicle-mediated transport. Predicted to be located in membrane. Predicted to be active in exocytic vesicle and plasma membrane. Is expressed in indirect flight muscle cell. Orthologous to human SYT12 (synaptotagmin 12). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Syt12 in Genome Data Viewer
Location:
11F1-11F1; 1-43 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13359248..13368179)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13253281..13262212)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45708 Neighboring gene long non-coding RNA:CR45709 Neighboring gene doublesex-Mab related 11E Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Astrocyte Ca(2+) Influx Negatively Regulates Neuronal Activity. Zhang YV, et al. eNeuro, 2017 Mar-Apr. PMID 28303263, Free PMC Article
  2. Peptidergic cell-specific synaptotagmins in Drosophila: localization to dense-core granules and regulation by the bHLH protein DIMMED. Park D, et al. J Neurosci, 2014 Sep 24. PMID 25253864, Free PMC Article
  3. Constraints, independence, and evolution of thermal plasticity: probing genetic architecture of long- and short-term thermal acclimation. Gerken AR, et al. Proc Natl Acad Sci U S A, 2015 Apr 7. PMID 25805817, Free PMC Article
  4. Function of Drosophila Synaptotagmins in membrane trafficking at synapses. Quiñones-Frías MC, et al. Cell Mol Life Sci, 2021 May. PMID 33619613, Free PMC Article
  5. Genetic and molecular analysis of the synaptotagmin family. Adolfsen B, et al. Cell Mol Life Sci, 2001 Mar. PMID 11315187, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion sensor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
synaptotagmin 12
Names
CG10617-PA
CG10617-PB
Syt12-PA
Syt12-PB
syt12

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13359248..13368179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132650.2 → NP_572878.1  synaptotagmin 12, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572878.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQJ2, Q9VYE1
    Related
    FBpp0073598
    Conserved Domains (2) summary
    cd08406
    Location:612 → 753
    C2B_Synaptotagmin-12; C2 domain second repeat present in Synaptotagmin 12
    pfam00168
    Location:503 → 602
    C2; C2 domain

  2. NM_001272584.1 → NP_001259513.1  synaptotagmin 12, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259513.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQJ2, Q9VYE1
    Conserved Domains (2) summary
    cd08406
    Location:612 → 753
    C2B_Synaptotagmin-12; C2 domain second repeat present in Synaptotagmin 12
    pfam00168
    Location:503 → 602
    C2; C2 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MQJ2 Q8MQJ2
Q9VYE1 Q9VYE1

Gene LinkOut

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