arg2 arginase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: arg2provided by ZNC
Official Full Name: arginase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1334
See related: Ensembl:ENSDARG00000039269 AllianceGenome:ZFIN:ZDB-GENE-030131-1334
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:65793; zgc:85630; wu:fb67g02
Summary: Predicted to enable arginase activity and manganese ion binding activity. Predicted to be involved in arginine catabolic process to ornithine. Predicted to act upstream of or within arginine metabolic process. Predicted to be active in mitochondrion. Is expressed in axial mesoderm; central nervous system; forerunner cell group; and integument. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ARG2 (arginase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (33024547..33034261)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (32894097..32903811)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An arginase 2 promoter transgenic line illuminates immune cell polarisation in zebrafish.
Title: An arginase 2 promoter transgenic line illuminates immune cell polarisation in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables arginase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arginase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arginine catabolic process to ornithine	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within arginine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within urea cycle	IEA Inferred from Electronic Annotation more info
involved_in urea cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: arginase-2, mitochondrial

Names: arginase, type II

NP_955905.1

EC 3.5.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.