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uqcrc2b ubiquinol-cytochrome c reductase core protein 2b [ Danio rerio (zebrafish) ]

Gene ID: 322549, updated on 9-Dec-2024

Summary

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Official Symbol
uqcrc2bprovided by ZNC
Official Full Name
ubiquinol-cytochrome c reductase core protein 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1269
See related
Ensembl:ENSDARG00000071691 AllianceGenome:ZFIN:ZDB-GENE-030131-1269
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
uqcrc2; fi06a11; wu:fb64g04; wu:fi06a11
Summary
Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be active in mitochondrion. Is expressed in gut and liver. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 5. Orthologous to human UQCRC2 (ubiquinol-cytochrome c reductase core protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See uqcrc2b in Genome Data Viewer
Location:
chromosome: 12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (10424679..10441639, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (10386836..10403796, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene transfer RNA leucine (anticodon UAG) Neighboring gene modulator of smoothened b Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein b (U4/U6.U5) Neighboring gene crystallin, mu

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish. Zou YY, et al. Front Endocrinol (Lausanne), 2023. PMID 37284220, Free PMC Article
  2. Mitochondrial DNA metabolism in early development of zebrafish (Danio rerio). Artuso L, et al. Biochim Biophys Acta, 2012 Jul. PMID 22465854
  3. Nucleoside supplementation modulates mitochondrial DNA copy number in the dguok -/- zebrafish. Munro B, et al. Hum Mol Genet, 2019 Mar 1. PMID 30428046, Free PMC Article
  4. A High-Fat Diet Induces Muscle Mitochondrial Dysfunction and Impairs Swimming Capacity in Zebrafish: A New Model of Sarcopenic Obesity. Zou YY, et al. Nutrients, 2022 May 9. PMID 35565942, Free PMC Article
  5. Altered glycometabolism in zebrafish exposed to thifluzamide. Yang Y, et al. Chemosphere, 2017 Sep. PMID 28535465

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome b-c1 complex subunit 2, mitochondrial
Names
ubiquinol-cytochrome c reductase core protein II
ubiquinol-cytochrome c reductase core protein IIb
NP_001001589.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001589.1 → NP_001001589.1  cytochrome b-c1 complex subunit 2, mitochondrial

    See identical proteins and their annotated locations for NP_001001589.1

    Status: PROVISIONAL

    Source sequence(s)
    BC071551
    UniProtKB/TrEMBL
    A0A8M1MZM2, Q6IQ59
    Related
    ENSDARP00000005930.7, ENSDART00000014379.8
    Conserved Domains (3) summary
    COG0612
    Location:39 → 432
    PqqL; Predicted Zn-dependent peptidase [General function prediction only]
    pfam00675
    Location:49 → 195
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:201 → 379
    Peptidase_M16_C; Peptidase M16 inactive domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    10424679..10441639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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