agt angiotensinogen [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: agtprovided by ZNC
Official Full Name: angiotensinogenprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1205
See related: Ensembl:ENSDARG00000016412 AllianceGenome:ZFIN:ZDB-GENE-030131-1205
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb62f06; wu:fj87b02; zgc:111892
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in regulation of apoptotic process. Predicted to act upstream of or within regulation of systemic arterial blood pressure by renin-angiotensin and vasoconstriction. Predicted to be active in extracellular space. Is expressed in brain; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (23988453..23995874)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (23858003..23865424)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Angiotensin-II promotes Na+ uptake in larval in acidic and ion-poor water.
Title: Angiotensin-II promotes Na+ uptake in larval zebrafish, Danio rerio, in acidic and ion-poor water.

Submit: New GeneRIF Correction

General gene information

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Markers

fb62f06.x1 (e-PCR)
- UniSTS:187318

fj87b02.x1 (e-PCR)
- UniSTS:200179

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of systemic arterial blood pressure by renin-angiotensin	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasoconstriction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: angiotensinogen

Names: zC8A9.1 (angiotensinogen )

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198063.1 → NP_932329.1 angiotensinogen precursor

See identical proteins and their annotated locations for NP_932329.1

Status: PROVISIONAL

Source sequence(s)

AY049731

UniProtKB/TrEMBL

A0A8M1P922, Q6ZM81, Q8JH29

Related

ENSDARP00000017923.2, ENSDART00000010918.5

Conserved Domains (1) summary

cd02054
Location:82 → 452

angiotensinogen; Angiotensinogen is part of the renin-angiotensin system (RAS), which plays an important role in blood pressure regulation, renal haemodynamics, fluid and electrolyte homeostasis. It is also involved in normal and abnormal growth processes. The growth ...