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hsdl2 hydroxysteroid dehydrogenase like 2 [ Danio rerio (zebrafish) ]

Gene ID: 322347, updated on 9-Dec-2024

Summary

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Official Symbol
hsdl2provided by ZNC
Official Full Name
hydroxysteroid dehydrogenase like 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1066
See related
Ensembl:ENSDARG00000002523 AllianceGenome:ZFIN:ZDB-GENE-030131-1066
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:73140; zgc:77693; wu:fb58f08
Summary
Predicted to enable oxidoreductase activity. Predicted to be located in peroxisome. Predicted to be active in mitochondrion. Orthologous to human HSDL2 (hydroxysteroid dehydrogenase like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See hsdl2 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (11265303..11280583)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (11303321..11322345)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101885184 Neighboring gene polypyrimidine tract binding protein 3 Neighboring gene KIAA1958 ortholog Neighboring gene ints3 and nabp interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Single and joint toxic effects of four antibiotics on some metabolic pathways of zebrafish (Danio rerio) larvae. Qiu W, et al. Sci Total Environ, 2020 May 10. PMID 32036144
  2. Beta-Hydroxysteroid Dehydrogenase Genes in Orange-Spotted Grouper (Epinephelus coioides): Genome-Wide Identification and Expression Analysis During Sex Reversal. Xiao L, et al. Front Genet, 2020. PMID 32194632, Free PMC Article
  3. Proteomic analysis of arsenic-exposed zebrafish (Danio rerio) identifies altered expression in proteins involved in fibrosis and lipid uptake in a gender-specific manner. Carlson P, et al. Toxicol Sci, 2013 Jul. PMID 23570992
  4. Molecular insights into 4-nitrophenol-induced hepatotoxicity in zebrafish: transcriptomic, histological and targeted gene expression analyses. Lam SH, et al. Biochim Biophys Acta, 2013 Oct. PMID 23791553
  5. Toxicogenomic analysis in the combined effect of tributyltin and benzo[a]pyrene on the development of zebrafish embryos. Huang L, et al. Aquat Toxicol, 2015 Jan. PMID 25438121

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hydroxysteroid dehydrogenase-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199599.2 → NP_955893.1  hydroxysteroid dehydrogenase-like protein 2

    See identical proteins and their annotated locations for NP_955893.1

    Status: PROVISIONAL

    Source sequence(s)
    BC062838
    UniProtKB/Swiss-Prot
    Q6P5L8
    Related
    ENSDARP00000038205.4, ENSDART00000038888.8
    Conserved Domains (3) summary
    cd09762
    Location:8 → 248
    HSDL2_SDR_c; human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs
    pfam00106
    Location:12 → 210
    adh_short; short chain dehydrogenase
    pfam02036
    Location:311 → 408
    SCP2; SCP-2 sterol transfer family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    11265303..11280583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P5L8.1 GenPept UniProtKB/Swiss-Prot:Q6P5L8

Gene LinkOut

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