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Agpat1 1-Acylglycerol-3-phosphate O-acyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32230, updated on 9-Dec-2024

Summary

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Official Symbol
Agpat1provided by FlyBase
Official Full Name
1-Acylglycerol-3-phosphate O-acyltransferase 1provided by FlyBase
Primary source
FLYBASE:FBgn0030421
Locus tag
Dmel_CG3812
See related
AllianceGenome:FB:FBgn0030421
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AGPAT; AGPAT1; AGPAT2; CG3812; dAGPAT1; DmAGPAT1/2; Dmel\CG3812
Summary
Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidic acid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 1 and lipodystrophy. Orthologous to several human genes including AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Agpat1 in Genome Data Viewer
Location:
11B16-11C1; 1-39 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12765266..12772851)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12659299..12666884)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene PAICS bifunctional enzyme Neighboring gene pirate Neighboring gene uncharacterized protein Neighboring gene Phosphodiesterase 9 Neighboring gene Neprilysin 6 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation. Tian Y, et al. PLoS Genet, 2011 Apr. PMID 21533227, Free PMC Article
  2. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Wilfling F, et al. Dev Cell, 2013 Feb 25. PMID 23415954, Free PMC Article
  3. Diverse roles of phosphatidate phosphatases in insect development and metabolism. Lehmann M. Insect Biochem Mol Biol, 2021 Jun. PMID 32931938, Free PMC Article
  4. Thematic review series: Lipid droplet synthesis and metabolism: from yeast to man. Lipid droplet-based storage fat metabolism in Drosophila. Kühnlein RP. J Lipid Res, 2012 Aug. PMID 22566574, Free PMC Article
  5. A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown. Wat LW, et al. PLoS Biol, 2020 Jan. PMID 31961851, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 12770914-12771560 mobile_element_type = transposon:1360{}115

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
1-Acylglycerol-3-phosphate O-acyltransferase 1
Names
Agpat1-PA
Agpat1-PB
Agpat1-PC
CG3812-PA
CG3812-PB
CG3812-PC
NP_001259494.1
NP_572828.1
NP_727641.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    12765266..12772851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167337.2 → NP_727641.1  1-Acylglycerol-3-phosphate O-acyltransferase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727641.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYJ4
    Related
    FBpp0073522
    Conserved Domains (1) summary
    cd07989
    Location:70 → 254
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

  2. NM_132600.2 → NP_572828.1  1-Acylglycerol-3-phosphate O-acyltransferase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572828.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYJ4
    Related
    FBpp0073521
    Conserved Domains (1) summary
    cd07989
    Location:70 → 254
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

  3. NM_001272565.1 → NP_001259494.1  1-Acylglycerol-3-phosphate O-acyltransferase 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259494.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYJ4
    Conserved Domains (1) summary
    cd07989
    Location:70 → 254
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VYJ4 Q9VYJ4

Gene LinkOut

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