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Paics PAICS bifunctional enzyme [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32228, updated on 9-Dec-2024

Summary

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Official Symbol
Paicsprovided by FlyBase
Official Full Name
PAICS bifunctional enzymeprovided by FlyBase
Primary source
FLYBASE:FBgn0020513
Locus tag
Dmel_CG3989
See related
AllianceGenome:FB:FBgn0020513
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ade5; Ade5; AIRc-SAICARs; CG3989; Dmel\CG3989
Summary
Enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Involved in 'de novo' IMP biosynthetic process. Located in cytosol. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; female germline cell; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Paics in Genome Data Viewer
Location:
11B16-11B16; 1-39 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12757036..12760617, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12651069..12654650, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene VSR interacting RNA Neighboring gene long non-coding RNA:CR44619 Neighboring gene pirate Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila melanogaster ade5 gene encodes a bifunctional enzyme for two steps in the de novo purine synthesis pathway. O'Donnell AF, et al. Genetics, 2000 Mar. PMID 10757766, Free PMC Article
  2. Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks. Cannavò E, et al. Curr Biol, 2016 Jan 11. PMID 26687625, Free PMC Article
  3. Zelda overcomes the high intrinsic nucleosome barrier at enhancers during Drosophila zygotic genome activation. Sun Y, et al. Genome Res, 2015 Nov. PMID 26335633, Free PMC Article
  4. Neurodegeneration of Drosophila drop-dead mutants is associated with hypoxia in the brain. Kim JY, et al. Genes Brain Behav, 2012 Mar. PMID 22010830
  5. piRNA-mediated gene regulation and adaptation to sex-specific transposon expression in D. melanogaster male germline. Chen P, et al. Genes Dev, 2021 Jun. PMID 33985970, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphoribosylaminoimidazole carboxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' IMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
PAICS bifunctional enzyme
Names
AIR-carboxylase-SAICAR synthetase
CG3989-PA
CG3989-PB
Paics-PA
Paics-PB
ade5
NP_001259493.1
NP_572826.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    12757036..12760617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272564.1 → NP_001259493.1  PAICS bifunctional enzyme, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259493.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F0JAN1
    Conserved Domains (2) summary
    cd01416
    Location:11 → 259
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:270 → 423
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein

  2. NM_132598.4 → NP_572826.1  PAICS bifunctional enzyme, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572826.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9I7S8, Q9TVK1
    Related
    FBpp0073538
    Conserved Domains (2) summary
    cd01416
    Location:12 → 260
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:271 → 424
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F0JAN1 F0JAN1
Q9I7S8.2 Q9I7S8

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