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eif5 eukaryotic translation initiation factor 5 [ Danio rerio (zebrafish) ]

Gene ID: 322256, updated on 4-Jan-2025

Summary

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Official Symbol
eif5provided by ZNC
Official Full Name
eukaryotic translation initiation factor 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-975
See related
Ensembl:ENSDARG00000003681 AllianceGenome:ZFIN:ZDB-GENE-030131-975
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb37c12; fb54h04; zgc:56606; zgc:77026; wu:fb37c12; wu:fb54h04
Summary
Predicted to enable GDP-dissociation inhibitor activity; eukaryotic initiation factor eIF2 binding activity; and translation initiation factor activity. Predicted to be involved in formation of cytoplasmic translation initiation complex. Predicted to act upstream of or within translational initiation. Predicted to be active in cytosol. Is expressed in lens. Orthologous to human EIF5 (eukaryotic translation initiation factor 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See eif5 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (18702796..18713949)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (18803168..18814366)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-72h1.1 Neighboring gene uncharacterized LOC137488636 Neighboring gene tumor necrosis factor, alpha-induced protein 2a Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 5 Neighboring gene family with sequence similarity 167 member Ab

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Disruption of Cxcr3 chemotactic signaling alters lysosomal function and renders macrophages more microbicidal. Sommer F, et al. Cell Rep, 2021 Apr 13. PMID 33852860
  2. The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection. Torraca V, et al. Dis Model Mech, 2015 Mar. PMID 25573892, Free PMC Article
  3. Genetic landscape of T cells identifies synthetic lethality for T-ALL. O'Meara CP, et al. Commun Biol, 2021 Oct 20. PMID 34671088, Free PMC Article
  4. RNAseq Profiling of Leukocyte Populations in Zebrafish Larvae Reveals a cxcl11 Chemokine Gene as a Marker of Macrophage Polarization During Mycobacterial Infection. Rougeot J, et al. Front Immunol, 2019. PMID 31110502, Free PMC Article
  5. Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation. Ozbudak EM, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20160088, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic initiation factor eIF2 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in formation of cytoplasmic translation initiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 5
Names
DKEYP-72H1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199591.2 → NP_955885.1  eukaryotic translation initiation factor 5

    See identical proteins and their annotated locations for NP_955885.1

    Status: PROVISIONAL

    Source sequence(s)
    BC066614
    UniProtKB/TrEMBL
    A0A2R8Q2R5, A0A2R8S0D9, Q7ZWA9
    Related
    ENSDARP00000147405.1, ENSDART00000181188.1
    Conserved Domains (2) summary
    cd11561
    Location:226 → 376
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:9 → 128
    eIF-5_eIF-2B; Domain found in IF2B/IF5

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    18702796..18713949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160454.4 → XP_005160511.1  eukaryotic translation initiation factor 5 isoform X1

    See identical proteins and their annotated locations for XP_005160511.1

    UniProtKB/TrEMBL
    A0A2R8Q2R5, A0A2R8S0D9, Q7ZWA9
    Related
    ENSDARP00000020566.7, ENSDART00000019476.9
    Conserved Domains (2) summary
    cd11561
    Location:226 → 376
    W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
    pfam01873
    Location:9 → 128
    eIF-5_eIF-2B; Domain found in IF2B/IF5
Nucleotide Protein
Heading Accession and Version

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