Tis11 Tis11 zinc finger protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tis11provided by FlyBase
Official Full Name: Tis11 zinc finger proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0011837
Locus tag: Dmel_CG4070
See related: AllianceGenome:FB:FBgn0011837
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Liang-1.28; CG4070; clone 1.28; Dmel\CG4070; dTis11; dTIS11; DTIS11; DTIS11-RC; dTTP; l(1)G0124; tis-11; tis11; TIS11; TIS11cc1; TIScc1; Ts11
Summary: Enables mRNA 3'-UTR AU-rich region binding activity. Involved in 3'-UTR-mediated mRNA destabilization; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in cytosol. Is expressed in adult brain cell body rind; adult gnathal ganglion; and organism. Orthologous to human ZFP36L1 (ZFP36 ring finger protein like 1) and ZFP36L2 (ZFP36 ring finger protein like 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 11B9-11B10; 1-39 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (12659415..12682560)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (12553448..12576587)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we observed that dtis11 expression contributes to cell metabolic and proliferative recovery upon reoxygenation. Altogether, our data demonstrate that AMD plays an important role in the control of gene expression upon variation in oxygen concentration and contributes to optimal metabolic adaptation to oxygen variations.
Title: ARE-mediated decay controls gene expression and cellular metabolism upon oxygen variations.
Data indicate that Tis11 protein can affect post-transcriptional gene expression in adult flies by regulating mRNA decay.
Title: The Drosophila Tis11 protein and its effects on mRNA expression in flies.
the Drosophila melanogaster dTIS11 protein is short-lived due to its rapid ubiquitin-independent degradation by the proteasome.
Title: Rapid proteasomal degradation of posttranscriptional regulators of the TIS11/tristetraprolin family is induced by an intrinsically unstructured region independently of ubiquitination.
Nuclear export of TIS11 proteins is mediated by CRM1 through diverging nuclear export signals, while their nuclear import mechanism may rely on a highly conserved signal whose activity is negatively regulated by ZnF2 folding.
Title: A masked PY-NLS in Drosophila TIS11 and its mammalian homolog tristetraprolin.
overexpression of dTIS11 does not promote the localization of ARE-containing mRNAs in P-bodies but rather decreases the accumulation of CecA1 mRNA in these structures by enhancing the degradation process
Title: dTIS11 Protein-dependent polysomal deadenylation is the key step in AU-rich element-mediated mRNA decay in Drosophila cells.
study identified a novel mRNA target of DTIS11, eya, and provided evidence that DTIS11 regulates eye development by interacting with and destabilizing eya mRNA, especially during embryogenesis
Title: Drosophila eyes absent is a novel mRNA target of the tristetraprolin (TTP) protein DTIS11.
The functionality of CecA1 ARE relies on its ability to recruit TIS11 protein, which accelerates CecA1 mRNA deadenylation and decay
Title: Post-transcriptional Regulation of Genes Encoding Anti-microbial Peptides in Drosophila.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables mRNA 3'-UTR AU-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Tis11 zinc finger protein

Names: CG4070-PA; CG4070-PC; CG4070-PD; Tis11 homolog; Tis11-PA; Tis11-PC; Tis11-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

12659415..12682560

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272561.2 → NP_001259490.1 Tis11 zinc finger protein, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259490.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P47980, Q8IR77, Q9VYK1

UniProtKB/TrEMBL

B3DN56

Conserved Domains (1) summary

pfam00642
Location:136 → 161

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
NM_078586.5 → NP_511141.2 Tis11 zinc finger protein, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511141.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P47980, Q8IR77, Q9VYK1

UniProtKB/TrEMBL

B3DN56

Related

FBpp0073516

Conserved Domains (1) summary

pfam00642
Location:136 → 161

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
NM_167333.4 → NP_727633.2 Tis11 zinc finger protein, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727633.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P47980, Q8IR77, Q9VYK1

UniProtKB/TrEMBL

B3DN56

Conserved Domains (1) summary

pfam00642
Location:136 → 161

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)