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Aven Apoptosis and caspase activation inhibitor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32215, updated on 4-Jan-2025

Summary

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Official Symbol
Avenprovided by FlyBase
Official Full Name
Apoptosis and caspase activation inhibitorprovided by FlyBase
Primary source
FLYBASE:FBgn0030410
Locus tag
Dmel_CG15727
See related
AllianceGenome:FB:FBgn0030410
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15727; dAven; Dmel\CG15727
Summary
Involved in negative regulation of G2/M transition of mitotic cell cycle. Located in cytosol and nucleus. Is expressed in several structures, including embryonic/larval salivary gland; epithelium; germ layer; larval tracheal system; and larval ventral nerve cord. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Aven in Genome Data Viewer
Location:
11B5-11B5; 1-39 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12628370..12629640, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12522403..12523673, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44568 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tomosyn Neighboring gene mir-970 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of dAven, a Drosophila melanogaster ortholog of the cell cycle regulator Aven. Zou S, et al. Cell Cycle, 2011 Mar 15. PMID 21368576, Free PMC Article
  2. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article
  3. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article
  4. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article
  5. Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Schnorrer F, et al. Nature, 2010 Mar 11. PMID 20220848

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
apoptosis and caspase activation inhibitor
Names
Aven-PA
Aven-PB
CG15727-PA
CG15727-PB
aven ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    12628370..12629640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298233.1 → NP_001285162.1  apoptosis and caspase activation inhibitor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285162.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYK8
    Conserved Domains (1) summary
    PRK12278
    Location:180 → 248
    PRK12278; 50S ribosomal protein L21/unknown domain fusion protein; Provisional

  2. NM_132589.2 → NP_572817.1  apoptosis and caspase activation inhibitor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572817.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYK8
    Related
    FBpp0073542, FBtr0073709
    Conserved Domains (1) summary
    PRK12278
    Location:180 → 248
    PRK12278; 50S ribosomal protein L21/unknown domain fusion protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VYK8 Q9VYK8

Gene LinkOut

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