wdr36 WD repeat domain 36 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wdr36provided by ZNC
Official Full Name: WD repeat domain 36provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-464
See related: Ensembl:ENSDARG00000004774 AllianceGenome:ZFIN:ZDB-GENE-030131-464
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66324; wu:fb33e10
Summary: Acts upstream of or within rRNA processing. Located in cytoplasm and nucleolus. Is expressed in digestive system; heart; immature eye; nervous system; and somite. Human ortholog(s) of this gene implicated in glaucoma and primary open angle glaucoma. Orthologous to human WDR36 (WD repeat domain 36). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (55866769..55914293, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (55196552..55244076, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Wdr36 function leads to an activation of the p53 stress-response pathway, suggesting that defects in p53 pathway may influence the impact of WDR36 variants on primary open-angle glaucoma.
Title: The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway.

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General gene information

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Markers

fb33e10 (e-PCR)
- UniSTS:189021

fb33e10.x1 (e-PCR)
- UniSTS:203119

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within rRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Pwp2p-containing subcomplex of 90S preribosome	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: WD repeat-containing protein 36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308831.1 → NP_001295760.1 WD repeat-containing protein 36

Status: VALIDATED

Source sequence(s)

BX294395

UniProtKB/TrEMBL

A0A8M1P741, A3KPR1

Related

ENSDARP00000008668.8, ENSDART00000014049.9

Conserved Domains (4) summary

COG2319
Location:101 → 519

WD40; WD40 repeat [General function prediction only]

pfam04192
Location:672 → 892

Utp21; Utp21 specific WD40 associated putative domain

sd00039
Location:150 → 189

7WD40; WD40 repeat [structural motif]

cl02567
Location:276 → 596

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...