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pcm1 pericentriolar material 1 [ Danio rerio (zebrafish) ]

Gene ID: 321709, updated on 9-Dec-2024

Summary

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Official Symbol
pcm1provided by ZNC
Official Full Name
pericentriolar material 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-428
See related
Ensembl:ENSDARG00000062198 AllianceGenome:ZFIN:ZDB-GENE-030131-428
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb30g01; wu:fb94e03; wu:fe14f07
Summary
Predicted to be involved in microtubule anchoring at centrosome; non-motile cilium assembly; and protein localization to centrosome. Predicted to act upstream of or within cilium assembly. Located in centrosome. Is expressed in head and post-vent region. Orthologous to human PCM1 (pericentriolar material 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See pcm1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (16621322..16654161)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (15928385..15961224)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 7b Neighboring gene microtubule associated tumor suppressor 1b Neighboring gene N-acylsphingosine amidohydrolase (acid ceramidase) 1b Neighboring gene uncharacterized LOC110439707

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia. Monroe TO, et al. Nat Commun, 2020 Nov 19. PMID 33214552, Free PMC Article
  2. The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium. Stowe TR, et al. Mol Biol Cell, 2012 Sep. PMID 22767577, Free PMC Article
  3. A BBSome subunit links ciliogenesis, microtubule stability, and acetylation. Loktev AV, et al. Dev Cell, 2008 Dec. PMID 19081074
  4. Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing. Li J, et al. Nucleic Acids Res, 2021 Feb 26. PMID 33476374, Free PMC Article
  5. Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish. Kok FO, et al. Dev Cell, 2015 Jan 12. PMID 25533206, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cilium assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within microtubule anchoring at centrosome IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein localization to centrosome IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pericentriolar material 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001115123.1 → NP_001108595.1  pericentriolar material 1 protein

    Status: PROVISIONAL

    Source sequence(s)
    AL935291
    UniProtKB/TrEMBL
    A0A8M1NI52, A0A8M9QB62
    Related
    ENSDARP00000136285.2, ENSDART00000164899.2
    Conserved Domains (1) summary
    pfam15717
    Location:1391 → 1989
    PCM1_C; Pericentriolar material 1 C terminus

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    16621322..16654161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009307141.3 → XP_009305416.1  pericentriolar material 1 protein isoform X1

    UniProtKB/TrEMBL
    A0A8M3B520, A0A8M9QAU8
    Conserved Domains (1) summary
    pfam15717
    Location:1437 → 2024
    PCM1_C; Pericentriolar material 1 C terminus

  2. XM_068223131.1 → XP_068079232.1  pericentriolar material 1 protein isoform X2

    UniProtKB/TrEMBL
    A0A8M9PSA8

  3. XM_068223196.1 → XP_068079297.1  pericentriolar material 1 protein isoform X6

    UniProtKB/TrEMBL
    A0A8M9QFV9

  4. XM_068223157.1 → XP_068079258.1  pericentriolar material 1 protein isoform X4

    UniProtKB/TrEMBL
    A0A8M9QJV5

  5. XM_009307146.3 → XP_009305421.1  pericentriolar material 1 protein isoform X3

    UniProtKB/TrEMBL
    A0A8M3AYV7, A0A8M9QFL3
    Conserved Domains (1) summary
    pfam15717
    Location:1426 → 2013
    PCM1_C; Pericentriolar material 1 C terminus

  6. XM_068223163.1 → XP_068079264.1  pericentriolar material 1 protein isoform X5

    UniProtKB/TrEMBL
    A0A8M9QB62
    Related
    ENSDARP00000124973.1, ENSDART00000149026.3

  7. XM_068223107.1 → XP_068079208.1  pericentriolar material 1 protein isoform X1

    UniProtKB/TrEMBL
    A0A8M3B520, A0A8M9QAU8

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394468.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    258827..289737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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