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Tango4 Transport and Golgi organization 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32168, updated on 4-Jan-2025

Summary

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Official Symbol
Tango4provided by FlyBase
Official Full Name
Transport and Golgi organization 4provided by FlyBase
Primary source
FLYBASE:FBgn0030365
Locus tag
Dmel_CG1796
See related
AllianceGenome:FB:FBgn0030365
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1796; Dmel\CG1796; tango4; TANGO4
Summary
Involved in Golgi organization and protein secretion. Located in cytosol. Part of Prp19 complex. Is expressed in adult head and organism. Orthologous to human PLRG1 (pleiotropic regulator 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Tango4 in Genome Data Viewer
Location:
11A1-11A1; 1-38 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12021068..12022746)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11915101..11916779)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene regucalcin Neighboring gene Chromatin accessibility complex 16kD protein Neighboring gene LSM12 homolog a Neighboring gene Ubiquitin-specific protease 7 Neighboring gene Cytochrome P450 311a1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Tendon Cell Specific RNAi Screen Reveals Novel Candidates Essential for Muscle Tendon Interaction. Tiwari P, et al. PLoS One, 2015. PMID 26488612, Free PMC Article
  2. Faint gray bands in Drosophila melanogaster polytene chromosomes are formed by coding sequences of housekeeping genes. Demakova OV, et al. Chromosoma, 2020 Mar. PMID 31820086
  3. Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development. Guilgur LG, et al. Elife, 2014 Apr 22. PMID 24755291, Free PMC Article
  4. Conserved regulators of nucleolar size revealed by global phenotypic analyses. Neumüller RA, et al. Sci Signal, 2013 Aug 20. PMID 23962978, Free PMC Article
  5. Identification of Evolutionarily Conserved Nuclear Matrix Proteins and Their Prokaryotic Origins. Sureka R, et al. J Proteome Res, 2021 Jan 1. PMID 33289389

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Prp19 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catalytic step 2 spliceosome HDA PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of precatalytic spliceosome HDA PubMed 

General protein information

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Preferred Names
transport and golgi organization 4
Names
CG1796-PA
Tango4-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    12021068..12022746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132550.3 → NP_572778.1  transport and golgi organization 4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572778.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYQ9
    Related
    FBpp0073459
    Conserved Domains (3) summary
    COG2319
    Location:161 → 458
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:164 → 458
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:177 → 212
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VYQ9 Q9VYQ9

Gene LinkOut

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