tsg twisted gastrulation [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tsgprovided by FlyBase
Official Full Name: twisted gastrulationprovided by FlyBase
Primary source: FLYBASE:FBgn0003865
Locus tag: Dmel_CG1502
See related: AllianceGenome:FB:FBgn0003865
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1502; Dmel\CG1502; dTsg; l(1)11Ab; l(1)11Ac; l(1)RF32; l(1)tsg; RF32; Tsg
Summary: Enables BMP binding activity; endopeptidase activator activity; and heparin binding activity. Involved in amnioserosa formation and negative regulation of BMP signaling pathway. Located in extracellular space. Is expressed in organism; parasegment 10; parasegment 4; and posterior transverse furrow. Orthologous to human TWSG1 (twisted gastrulation BMP signaling modulator 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (11988062..11988948, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (11882095..11882981, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Robustness of the BMP morphogen gradient in Drosophila embryonic patterning
Title: Robustness of the BMP morphogen gradient in Drosophila embryonic patterning.
Data suggest that decapentaplegic (Dpp)concentration dependence, together with movement of Dpp by Sog and Tsg proteins, can explain how Tld activity is confined to the dorsal-most region of the embryo.
Title: Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables BMP binding	IPI Inferred from Physical Interaction more info	PubMed
enables endopeptidase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in amnioserosa formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

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