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smc2 structural maintenance of chromosomes 2 [ Danio rerio (zebrafish) ]

Gene ID: 321452, updated on 4-Jan-2025

Summary

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Official Symbol
smc2provided by ZNC
Official Full Name
structural maintenance of chromosomes 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-105
See related
Ensembl:ENSDARG00000017744 AllianceGenome:ZFIN:ZDB-GENE-030131-105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
SMC2L1; fb92e05; zeh1628; zgc:55326; wu:fb92e05
Summary
Predicted to enable chromatin binding activity. Acts upstream of or within DNA damage response and liver development. Predicted to be located in chromatin. Predicted to be part of condensin complex. Predicted to be active in condensed chromosome. Is expressed in several structures, including blood vessel; digestive system; nervous system; optic vesicle; and pectoral fin. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human SMC2 (structural maintenance of chromosomes 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See smc2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (19538299..19561801)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (18845362..18868864)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene clarin 2 Neighboring gene exocyst complex component 1 like Neighboring gene Ecm29 proteasome adaptor and scaffold Neighboring gene F-box protein 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The Zebrafish Meiotic Cohesin Complex Protein Smc1b Is Required for Key Events in Meiotic Prophase I. Islam KN, et al. Front Cell Dev Biol, 2021. PMID 34434933, Free PMC Article
  2. Expression of cohesin and condensin genes during zebrafish development supports a non-proliferative role for cohesin. Mönnich M, et al. Gene Expr Patterns, 2009 Dec. PMID 19723591
  3. Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish. Ma D, et al. Proc Natl Acad Sci U S A, 2012 Dec 18. PMID 23213226, Free PMC Article
  4. Functions of SMC2 in the Development of Zebrafish Liver. Li X, et al. Biomedicines, 2021 Sep 16. PMID 34572426, Free PMC Article
  5. Regulation of E2F1 by the von Hippel-Lindau tumour suppressor protein predicts survival in renal cell cancer patients. Mans DA, et al. J Pathol, 2013 Sep. PMID 23744542

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chromosome condensation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in condensed chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
structural maintenance of chromosomes protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199542.2 → NP_955836.2  structural maintenance of chromosomes protein 2

    Status: VALIDATED

    Source sequence(s)
    BX548248
    UniProtKB/TrEMBL
    A0A8M1PBH0, B8A5K9, E7F2I1
    Related
    ENSDARP00000104167.3, ENSDART00000109416.4
    Conserved Domains (6) summary
    pfam06673
    Location:252 → 465
    L_lactis_ph-MCP; Lactococcus lactis bacteriophage major capsid protein
    cd03273
    Location:1 → 156
    ABC_SMC2_euk; ATP-binding cassette domain of eukaryotic SMC2 proteins
    smart00968
    Location:522 → 639
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:1 → 1170
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam13863
    Location:740 → 841
    DUF4200; Domain of unknown function (DUF4200)
    cl21455
    Location:1074 → 1169
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    19538299..19561801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394474.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    75483..98985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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