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CkIIbeta Casein kinase II beta subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32132, updated on 4-Jan-2025

Summary

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Official Symbol
CkIIbetaprovided by FlyBase
Official Full Name
Casein kinase II beta subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0000259
Locus tag
Dmel_CG15224
See related
AllianceGenome:FB:FBgn0000259
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
And; betaCK2; Cask-II-b; CCK2; CG15224; CK II; CK-2; CK-II beta; Ck-IIbeta; CK-IIbeta; CK2; CK2-beta; ck2beta; Ck2beta; CK2beta; CkII; CKII; CKII beta; CkII-beta; CKII-beta1; CKIIb; Ckiibeta; CKIIbeta; CkIIbeta1; dCK2beta; dCKII; dCKII beta; Dm-CK2-beta; DmCK2beta; DmCkIIbeta; DmCKIIbeta; Dmel\CG15224; Ds cas kin; KC2B_DROME; mbu
Summary
Enables protein kinase regulator activity. Involved in several processes, including locomotor rhythm; mushroom body development; and oocyte dorsal/ventral axis specification. Located in cytosol and nucleus. Part of protein kinase CK2 complex. Is active in neuromuscular junction and presynaptic cytosol. Is expressed in adult head. Orthologous to human CSNK2B (casein kinase 2 beta). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CkIIbeta in Genome Data Viewer
Location:
10E3-10E3; 1-36 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11792533..11801587)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11686566..11695620)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene dusky Neighboring gene antisense RNA:CR44962 Neighboring gene karl Neighboring gene Heat shock protein 70 cognate 3 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of proteins that interact with Drosophila melanogaster protein kinase CK2. Trott RL, et al. Mol Cell Biochem, 2001 Nov. PMID 11827179
  2. Multiple, closely spaced alternative 5' exons in the DmCKIIbeta gene of Drosophila melanogaster. Bidwai AP, et al. Mol Cell Biol Res Commun, 2000 May. PMID 10964752
  3. An inhibitory effect of actin on casein kinase II activity in vitro. Karino A, et al. FEBS Lett, 1996 Dec 2. PMID 8977130
  4. Chemical features of the protein kinase CK2 polyamine binding site. Leroy D, et al. Biochemistry, 1997 Feb 11. PMID 9063872
  5. Reconstitution of heterologous and chimeric casein kinase II with recombinant subunits from human and Drosophila: identification of species-specific differences in the beta subunit. Lin WJ, et al. J Protein Chem, 1994 Feb. PMID 8060494

See all (175) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data (including data from studies using transgenic animals) suggest that catalytic activity of casein kinase 2 (CkIIa/CkIIb) is essential for oogenesis in this species; Jabba, a lipid droplet-associated protein and substrate for casein kinase 2, is essential in modulating ovarian lipid metabolism. (CkIIa = casein kinase II alpha subunit; CkIIb = casein kinase II beta subunit)
    Title: The protein kinase CK2 substrate Jabba modulates lipid metabolism during Drosophila oogenesis.
  2. Drosophila splicing factor P element Somatic Inhibitor (PSI) is phosphorylated at at least two different sites by at minimum two different kinases, casein kinase II (CK II) and tousled-like kinase (tlk).
    Title: The Drosophila splicing factor PSI is phosphorylated by casein kinase II and tousled-like kinase.
  3. Coexpressing CK2alpha and CK2beta increases Smo accumulation and induces ectopic Hh target gene expression.
    Title: Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus.
  4. This study implicates a role for DmCK2beta in cell proliferation or cell survival during brain development.
    Title: In vivo functional analysis of Drosophila protein kinase casein kinase 2 (CK2) beta-subunit.
  5. CK2(beta)tes encodes a testis-specific isoform of the regulatory subunit of casein kinase 2
    Title: CK2(beta)tes gene encodes a testis-specific isoform of the regulatory subunit of casein kinase 2 in Drosophila melanogaster.
  6. ZFP47 is a new physiological partner and substrate of CK2.
    Title: A gene located at 72A in Drosophila melanogaster encodes a novel zinc-finger protein that interacts with protein kinase CK2.
  7. Identification and characterization of proteins that interact with Drosophila melanogaster protein kinase CK2
    Title: Identification and characterization of proteins that interact with Drosophila melanogaster protein kinase CK2.
  8. The DmCK2beta transcription unit encodes for functionally non-redundant protein isoforms.
    Title: The Drosophila melanogaster DmCK2beta transcription unit encodes for functionally non-redundant protein isoforms.
  9. results reveal a potential mechanism for regulation of the dMi-2 enzyme and point toward CK2 phosphorylation as a common feature of CHD family ATPases
    Title: dMi-2 chromatin binding and remodeling activities are regulated by dCK2 phosphorylation.
  10. CK2beta is localized within clock neurons and the clock proteins Period (Per) and Timeless (Tim) accumulate to abnormally high levels in the Andante mutant, suggesting a function for CK2-dependent phosphorylation in the molecular oscillator
    Title: A role for CK2 in the Drosophila circadian oscillator.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in eclosion rhythm TAS
Traceable Author Statement
more info
 PubMed 
involved_in intracellular mRNA localization involved in pattern specification process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mushroom body development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte dorsal/ventral axis specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in oocyte dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rhythmic behavior TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein kinase CK2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein kinase CK2 complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
casein kinase II beta subunit
Names
CG15224-PB
CG15224-PC
CG15224-PD
CG15224-PE
CG15224-PF
CG15224-PG
CG15224-PH
CG15224-PI
CG15224-PJ
CG15224-PK
CK2 (beta subunit)
CkIIbeta-PB
CkIIbeta-PC
CkIIbeta-PD
CkIIbeta-PE
CkIIbeta-PF
CkIIbeta-PG
CkIIbeta-PH
CkIIbeta-PI
CkIIbeta-PJ
CkIIbeta-PK
andante
casein kinase 2
casein kinase 2 regulatory subunit
casein kinase II
casein kinase II beta
mushroom bodies undersized

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11792533..11801587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206692.3 → NP_996415.1  casein kinase II beta subunit, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996415.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08182, Q76NS4, Q9VYU4
    UniProtKB/TrEMBL
    C9QPE1
    Conserved Domains (1) summary
    smart01085
    Location:8 → 191
    CK_II_beta; Casein kinase II regulatory subunit

  2. NM_080762.4 → NP_542940.1  casein kinase II beta subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_542940.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V4C1, C9QPE1
    Related
    FBpp0073403
    Conserved Domains (1) summary
    smart01085
    Location:8 → 191
    CK_II_beta; Casein kinase II regulatory subunit

  3. NM_001258701.2 → NP_001245630.1  casein kinase II beta subunit, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245630.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPE1, M9NGA3
    Conserved Domains (1) summary
    smart01085
    Location:8 → 191
    CK_II_beta; Casein kinase II regulatory subunit

  4. NM_001258699.1 → NP_001245628.1  casein kinase II beta subunit, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245628.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V4C1, C9QPE1
    Conserved Domains (1) summary
    smart01085
    Location:8 → 191
    CK_II_beta; Casein kinase II regulatory subunit

  5. NM_001258700.2 → NP_001245629.1  casein kinase II beta subunit, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245629.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPE1, M9NDU6
    Conserved Domains (1) summary
    smart01085
    Location:8 → 191
    CK_II_beta; Casein kinase II regulatory subunit

  6. NM_001272533.1 → NP_001259462.1  casein kinase II beta subunit, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259462.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPE1, M9PHA6
    Conserved Domains (1) summary
    smart01085
    Location:8 → 191
    CK_II_beta; Casein kinase II regulatory subunit

  7. NM_167304.3 → NP_727561.1  casein kinase II beta subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727561.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V4C1, C9QPE1
    Related
    FBpp0073405
    Conserved Domains (1) summary
    smart01085
    Location:8 → 191
    CK_II_beta; Casein kinase II regulatory subunit

  8. NM_001014731.2 → NP_001014731.1  casein kinase II beta subunit, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014731.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V4C1, C9QPE1
    Conserved Domains (1) summary
    smart01085
    Location:8 → 191
    CK_II_beta; Casein kinase II regulatory subunit

  9. NM_078576.5 → NP_511131.3  casein kinase II beta subunit, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511131.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V4C1, C9QPE1
    Conserved Domains (1) summary
    smart01085
    Location:8 → 191
    CK_II_beta; Casein kinase II regulatory subunit

  10. NM_167305.3 → NP_727562.1  casein kinase II beta subunit, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727562.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V4C1, C9QPE1
    Related
    FBpp0073406
    Conserved Domains (1) summary
    smart01085
    Location:8 → 191
    CK_II_beta; Casein kinase II regulatory subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V4C1 A4V4C1
M9NDU6 M9NDU6
M9NGA3 M9NGA3
M9PHA6 M9PHA6
P08182.2 P08182
Q9NGY7 Q9NGY7
Q9NGY8 Q9NGY8
Q9NGY9 Q9NGY9

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