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prtp pretaporter [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32124, updated on 4-Jan-2025

Summary

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Official Symbol
prtpprovided by FlyBase
Official Full Name
pretaporterprovided by FlyBase
Primary source
FLYBASE:FBgn0030329
Locus tag
Dmel_CG1837
See related
AllianceGenome:FB:FBgn0030329
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey253; CG1837; Dmel\CG1837; p47; Prtp
Summary
Predicted to enable protein disulfide isomerase activity. Involved in apoptotic cell clearance and positive regulation of apoptotic cell clearance. Located in endoplasmic reticulum. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval fat body; and head mesoderm. Orthologous to human TXNDC5 (thioredoxin domain containing 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See prtp in Genome Data Viewer
Location:
10D7-10D7; 1-35 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11716756..11719894)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11610789..11613927)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mir-9370 stem loop Neighboring gene amun Neighboring gene long non-coding RNA:CR45618 Neighboring gene Transport and Golgi organization 10 Neighboring gene uncharacterized protein Neighboring gene inaF-D Neighboring gene inaF-B Neighboring gene inaF-C Neighboring gene inaF-A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear localization of Pretaporter in Drosophila melanogaster third-instar larvae salivary gland and its deficiency-associated nuclear phenotype. Silvera MC, et al. MicroPubl Biol, 2024. PMID 39205673, Free PMC Article
  2. Role of NPxY motif in Draper-mediated apoptotic cell clearance in Drosophila. Fujita Y, et al. Drug Discov Ther, 2012 Dec. PMID 23337816
  3. Apoptosis-dependent externalization and involvement in apoptotic cell clearance of DmCaBP1, an endoplasmic reticulum protein of Drosophila. Okada R, et al. J Biol Chem, 2012 Jan 27. PMID 22158613, Free PMC Article
  4. Complement-Related Regulates Autophagy in Neighboring Cells. Lin L, et al. Cell, 2017 Jun 29. PMID 28666117, Free PMC Article
  5. Fragile X mental retardation protein coordinates neuron-to-glia communication for clearance of developmentally transient brain neurons. Song C, et al. Proc Natl Acad Sci U S A, 2023 Mar 21. PMID 36920921, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein disulfide isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
pretaporter
Names
CG1837-PA
CG1837-PB
CG1837-PC
CG1837-PD
pret-a-porter
prtp-PA
prtp-PB
prtp-PC
prtp-PD
NP_001188583.1
NP_001188584.1
NP_001259460.1
NP_572742.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11716756..11719894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201654.2 → NP_001188583.1  pretaporter, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188583.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9PGX2, Q9VYV3
    Conserved Domains (2) summary
    cd03005
    Location:167 → 267
    PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
    TIGR01130
    Location:39 → 409
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

  2. NM_001201655.2 → NP_001188584.1  pretaporter, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188584.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9PGX2, Q9VYV3
    Conserved Domains (2) summary
    cd03005
    Location:167 → 267
    PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
    TIGR01130
    Location:39 → 409
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

  3. NM_132514.3 → NP_572742.1  pretaporter, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572742.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9PGX2, Q9VYV3
    Related
    FBpp0073396
    Conserved Domains (2) summary
    cd03005
    Location:167 → 267
    PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
    TIGR01130
    Location:39 → 409
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

  4. NM_001272531.1 → NP_001259460.1  pretaporter, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259460.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VYV3
    Conserved Domains (3) summary
    cd03005
    Location:104 → 204
    PDI_a_ERp46; PDIa family, endoplasmic reticulum protein 46 (ERp46) subfamily; ERp46 is an ER-resident protein containing three redox active TRX domains. Yeast complementation studies show that ERp46 can substitute for protein disulfide isomerase (PDI) function in ...
    TIGR01130
    Location:2 → 346
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    cl00388
    Location:2 → 77
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VYV3.2 Q9VYV3

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