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PhKgamma Phosphorylase kinase gamma [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32120, updated on 9-Dec-2024

Summary

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Official Symbol
PhKgammaprovided by FlyBase
Official Full Name
Phosphorylase kinase gammaprovided by FlyBase
Primary source
FLYBASE:FBgn0011754
Locus tag
Dmel_CG1830
See related
AllianceGenome:FB:FBgn0011754
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-sts6; CG1830; Dmel\CG1830; DPhK-gamma; EP779; ESTS:194B3T; PhKg; Phkgamma; phkgamma CES
Summary
Predicted to enable phosphorylase kinase activity. Involved in embryonic morphogenesis. Predicted to be part of phosphorylase kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; mesoderm; and spermatozoon. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease IXc; and liver cirrhosis. Orthologous to several human genes including PHKG2 (phosphorylase kinase catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See PhKgamma in Genome Data Viewer
Location:
10D5-10D5; 1-35 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11695137..11704394)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11589170..11598427)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Valette Neighboring gene bifocal Neighboring gene uncharacterized protein Neighboring gene alpha1,6-fucosyltransferase Neighboring gene mir-9370 stem loop Neighboring gene amun

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DPhK-gamma, a putative Drosophila kinase with homology to vertebrate phosphorylase kinase gamma subunits: molecular characterisation of the gene and phenotypic analysis of loss of function mutants. Bahri SM, et al. Mol Gen Genet, 1994 Dec 1. PMID 7808409
  2. The Drosophila bifocal gene encodes a novel protein which colocalizes with actin and is necessary for photoreceptor morphogenesis. Bahri SM, et al. Mol Cell Biol, 1997 Sep. PMID 9271427, Free PMC Article
  3. Increased extracellular adenosine in Drosophila that are deficient in adenosine deaminase activates a release of energy stores leading to wasting and death. Zuberova M, et al. Dis Model Mech, 2010 Nov-Dec. PMID 20940317
  4. Predicting mutually exclusive spliced exons based on exon length, splice site and reading frame conservation, and exon sequence homology. Pillmann H, et al. BMC Bioinformatics, 2011 Jun 30. PMID 21718515, Free PMC Article
  5. Drosophila Dosage Compensation Loci Associate with a Boundary-Forming Insulator Complex. Kaye EG, et al. Mol Cell Biol, 2017 Nov 1. PMID 28784719, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorylase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphorylase kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of glycogen catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphorylase kinase complex IEA
Inferred from Electronic Annotation
more info
  
part_of phosphorylase kinase complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
phosphorylase kinase gamma
Names
CG1830-PB
CG1830-PD
CG1830-PE
CG1830-PF
CG1830-PH
PhKgamma-PB
PhKgamma-PD
PhKgamma-PE
PhKgamma-PF
PhKgamma-PH
NP_001285133.1
NP_001285134.1
NP_511129.3
NP_727548.1
NP_727549.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11695137..11704394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167296.3 → NP_727548.1  phosphorylase kinase gamma, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727548.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961E7
    Related
    FBpp0089045
    Conserved Domains (2) summary
    smart00220
    Location:23 → 291
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14093
    Location:19 → 291
    STKc_PhKG; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit

  2. NM_167297.3 → NP_727549.2  phosphorylase kinase gamma, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727549.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23996, Q7K4Y9, Q9I7D0, Q9VYV7
    Conserved Domains (2) summary
    smart00220
    Location:23 → 291
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14093
    Location:19 → 291
    STKc_PhKG; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit

  3. NM_001298205.1 → NP_001285134.1  phosphorylase kinase gamma, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285134.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961E7
    Conserved Domains (2) summary
    smart00220
    Location:23 → 291
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14093
    Location:19 → 291
    STKc_PhKG; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit

  4. NM_001298204.1 → NP_001285133.1  phosphorylase kinase gamma, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285133.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JEJ4
    Conserved Domains (2) summary
    smart00220
    Location:23 → 291
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14093
    Location:19 → 291
    STKc_PhKG; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit

  5. NM_078574.4 → NP_511129.3  phosphorylase kinase gamma, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511129.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23996, Q7K4Y9, Q9I7D0, Q9VYV7
    Conserved Domains (2) summary
    smart00220
    Location:23 → 291
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14093
    Location:19 → 291
    STKc_PhKG; Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q961E7 Q961E7
Q9I7D0 Q9I7D0
Q9VYV7 Q9VYV7
X2JEJ4 X2JEJ4

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