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Ptp10D Protein tyrosine phosphatase 10D [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32115, updated on 4-Jan-2025

Summary

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Official Symbol
Ptp10Dprovided by FlyBase
Official Full Name
Protein tyrosine phosphatase 10Dprovided by FlyBase
Primary source
FLYBASE:FBgn0004370
Locus tag
Dmel_CG1817
See related
AllianceGenome:FB:FBgn0004370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
10D; CG1817; CT4920; Dmel\CG1817; dptp; DPTP; Dptp10D; DPTP10D; DPTP[[10D]]; Ptp10; ptp10d; ptp10D; Ptp10d; PTP10D; R-PTP 10D; RPTP10d
Summary
Enables transmembrane receptor protein tyrosine phosphatase activity. Involved in several processes, including long-term memory; negative regulation of signal transduction; and nervous system development. Located in apical part of cell and axon. Is expressed in several structures, including adult antennal lobe; adult central complex; brain; embryonic/larval tracheal section; and tract. Human ortholog(s) of this gene implicated in angiosarcoma; breast angiosarcoma; carcinoma (multiple); central nervous system cancer (multiple); and sarcoma. Orthologous to human PTPRB (protein tyrosine phosphatase receptor type B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ptp10D in Genome Data Viewer
Location:
10D1-10D4; 1-35 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11622015..11677338)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11516048..11571371)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Replication protein A3 Neighboring gene Methoprene-tolerant Neighboring gene Valette Neighboring gene bifocal

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleotide diversity inflation as a genome-wide response to experimental lifespan extension in Drosophila melanogaster. Michalak P, et al. BMC Genomics, 2017 Jan 14. PMID 28088192, Free PMC Article
  2. Receptor-like tyrosine phosphatase PTP10D is required for long-term memory in Drosophila. Qian M, et al. J Neurosci, 2007 Apr 18. PMID 17442824, Free PMC Article
  3. Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D. Madan LL, et al. Biochemistry, 2011 Nov 22. PMID 22007620, Free PMC Article
  4. DPhK-gamma, a putative Drosophila kinase with homology to vertebrate phosphorylase kinase gamma subunits: molecular characterisation of the gene and phenotypic analysis of loss of function mutants. Bahri SM, et al. Mol Gen Genet, 1994 Dec 1. PMID 7808409
  5. Two Drosophila receptor-like tyrosine phosphatase genes are expressed in a subset of developing axons and pioneer neurons in the embryonic CNS. Yang XH, et al. Cell, 1991 Nov 15. PMID 1657401

See all (128) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. through a genetic screen in Drosophila, we identify the ligand Sas and the receptor-type tyrosine phosphatase PTP10D as the cell-surface ligand-receptor system that drives tumour-suppressive cell competition
    Title: The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition.
  2. The study of this study showed that neuronal Ptp10D restrains signaling by overexpressed glial Sas, which would otherwise produce strong glial and axonal phenotypes.
    Title: Interactions between a receptor tyrosine phosphatase and a cell surface ligand regulate axon guidance and glial-neuronal communication.
  3. Described is the crystal structures of Drosophila melanogaster PTP10D in the apo form as well as in a complex with a substrate peptide and an inhibitor.
    Title: Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D.
  4. Results describe a unique tracheal tubulogenesis phenotype caused by loss of both Drosophila type III receptor tyrosine phosphatases (RPTPs), Ptp4E and Ptp10D.
    Title: Receptor tyrosine phosphatases control tracheal tube geometries through negative regulation of Egfr signaling.
  5. Unlike Ptp10D, Ptp4E appears to be a relatively minor player in the control of axon guidance
    Title: Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily.
  6. Ptp10D is expressed only on the innermost core fibers during development of the larval mushroom body.
    Title: Receptor tyrosine phosphatases regulate birth order-dependent axonal fasciculation and midline repulsion during development of the Drosophila mushroom body.
  7. Our data clearly demonstrate that signaling through PTP10D in mushroom bodies is critical for the formation of long-term memory.
    Title: Receptor-like tyrosine phosphatase PTP10D is required for long-term memory in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in axon guidance IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in branching involved in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell signaling via exosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in central nervous system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in motor neuron axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in open tracheal system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein tyrosine phosphatase 10D
Names
CG1817-PB
CG1817-PE
CG1817-PF
CG1817-PG
CG1817-PH
CG1817-PI
Ptp10D-PB
Ptp10D-PE
Ptp10D-PF
Ptp10D-PG
Ptp10D-PH
Ptp10D-PI
protein tyrosine phosphatase 10B
NP_001138187.1
NP_001259453.1
NP_001259454.1
NP_727544.2
NP_996413.2
NP_996414.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11622015..11677338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206691.3 → NP_996414.2  protein tyrosine phosphatase 10D, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996414.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4B4, B7Z142, F0JAM3, M9PEB6, M9PJI5, P35992, Q0KHT5, Q86NN9, Q8IR87, Q9VYW1
    Conserved Domains (4) summary
    smart00194
    Location:1272 → 1525
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1298 → 1525
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:583 → 671
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:220 → 304
    fn3; Fibronectin type III domain

  2. NM_001144715.2 → NP_001138187.1  protein tyrosine phosphatase 10D, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138187.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35992
    Conserved Domains (4) summary
    smart00194
    Location:1272 → 1525
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1298 → 1525
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:583 → 671
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:220 → 304
    fn3; Fibronectin type III domain

  3. NM_001272525.1 → NP_001259454.1  protein tyrosine phosphatase 10D, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259454.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35992
    Conserved Domains (4) summary
    smart00194
    Location:1272 → 1525
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1298 → 1525
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:583 → 671
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:220 → 304
    fn3; Fibronectin type III domain

  4. NM_001272524.1 → NP_001259453.1  protein tyrosine phosphatase 10D, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259453.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35992
    Conserved Domains (4) summary
    smart00194
    Location:1294 → 1547
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1320 → 1547
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:599 → 687
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:236 → 320
    fn3; Fibronectin type III domain

  5. NM_206690.2 → NP_996413.2  protein tyrosine phosphatase 10D, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996413.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V4B4, B7Z142, F0JAM3, M9PEB6, M9PJI5, P35992, Q0KHT5, Q86NN9, Q8IR87, Q9VYW1
    Conserved Domains (4) summary
    smart00194
    Location:1272 → 1525
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1298 → 1525
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:583 → 671
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:220 → 304
    fn3; Fibronectin type III domain

  6. NM_167292.3 → NP_727544.2  protein tyrosine phosphatase 10D, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727544.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35992
    Conserved Domains (4) summary
    smart00194
    Location:1272 → 1525
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1298 → 1525
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:583 → 671
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:220 → 304
    fn3; Fibronectin type III domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35992.4 P35992

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