rtca RNA 3'-terminal phosphate cyclase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rtcaprovided by ZNC
Official Full Name: RNA 3'-terminal phosphate cyclaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9687
See related: Ensembl:ENSDARG00000002215 AllianceGenome:ZFIN:ZDB-GENE-030131-9687
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb158; rtcd1; sb:cb158; zgc:56339; wu:fc62c03
Summary: Predicted to enable RNA-3'-phosphate cyclase activity. Predicted to act upstream of or within RNA processing. Predicted to be active in nucleus. Is expressed in several structures, including axis; lateral plate mesoderm; nervous system; neural plate; and primordial germ cell. Orthologous to human RTCA (RNA 3'-terminal phosphate cyclase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (16282144..16291033, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (16255874..16264795, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc88a04.y1 (e-PCR)
- UniSTS:194722

fc62c03.x1 (e-PCR)
- UniSTS:203943

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA-3'-phosphate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA-3'-phosphate cyclase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA 3'-terminal phosphate cyclase

Names: RNA terminal phosphate cyclase domain 1; RTC domain containing 1

NP_955830.1

EC 6.5.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199536.2 → NP_955830.1 RNA 3'-terminal phosphate cyclase

See identical proteins and their annotated locations for NP_955830.1

Status: PROVISIONAL

Source sequence(s)

AY398409

UniProtKB/TrEMBL

F6NVV3, Q6TGU7, Q7ZUX5

Related

ENSDARP00000023892.9, ENSDART00000021666.10

Conserved Domains (2) summary

cd00874
Location:8 → 339

RNA_Cyclase_Class_II; RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine residue is found in ...

pfam01137
Location:12 → 337

RTC; RNA 3'-terminal phosphate cyclase