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ap2m1a adaptor related protein complex 2 subunit mu 1a [ Danio rerio (zebrafish) ]

Gene ID: 321051, updated on 9-Dec-2024

Summary

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Official Symbol
ap2m1aprovided by ZNC
Official Full Name
adaptor related protein complex 2 subunit mu 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9784
See related
Ensembl:ENSDARG00000002790 AllianceGenome:ZFIN:ZDB-GENE-030131-9784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb34; Ap2m1; dpy-23; sb:cb34; zgc:55711; zgc:85653; wu:fa97a10
Summary
Predicted to enable clathrin adaptor activity. Acts upstream of or within Wnt signaling pathway. Predicted to be located in clathrin-coated pit and plasma membrane. Predicted to be part of AP-2 adaptor complex. Predicted to be active in cytoplasmic vesicle. Is expressed in blood; mesoderm; notochord; sensory system; and solid lens vesicle. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human AP2M1 (adaptor related protein complex 2 subunit mu 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See ap2m1a in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (9789820..9818673, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (9992000..10020853, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:ch1073-170o4.1 Neighboring gene small nucleolar RNA SNORA13 Neighboring gene phosphate cytidylyltransferase 1A, choline a Neighboring gene annexin A13, like Neighboring gene si:ch211-252f13.5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification and functional characterization of AP-2 complex subunit mu-A as a new member of antimicrobial protein. Gong Y, et al. Dev Comp Immunol, 2021 Aug. PMID 33848529
  2. In vivo analysis of formation and endocytosis of the Wnt/β-catenin signaling complex in zebrafish embryos. Hagemann AI, et al. J Cell Sci, 2014 Sep 15. PMID 25074807, Free PMC Article
  3. A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect. Hsu CH, et al. Sci Rep, 2015 Jun 3. PMID 26039894, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification and functional characterization of AP-2 complex subunit mu-A as a new member of antimicrobial protein.
    Title: Identification and functional characterization of AP-2 complex subunit mu-A as a new member of antimicrobial protein.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-2 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AP-2 complex subunit mu-A
Names
AP-2 complex subunit mu-1-A
AP-2 mu-2 chain A
AP-2 mu-A chain
adaptor protein complex AP-2, mu1
adaptor-related protein complex 2, mu 1 subunit, a
clathrin assembly protein complex 2 medium chain A
clathrin assembly protein complex 2 mu-A medium chain
clathrin coat assembly protein AP50-A
clathrin coat-associated protein AP50-A
mu2-adaptin-A
plasma membrane adaptor AP-2 50 kDa protein A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291355.1 → NP_001278284.1  AP-2 complex subunit mu-A isoform 1

    See identical proteins and their annotated locations for NP_001278284.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    BX470264, EB766597, EH432280, EH456153
    UniProtKB/TrEMBL
    A0A8M1P618, A0A8M2B673, F1Q9V1, F1RD00
    Related
    ENSDARP00000106819.2, ENSDART00000124051.3
    Conserved Domains (1) summary
    cd09251
    Location:168 → 440
    AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2

  2. NM_212577.2 → NP_997742.1  AP-2 complex subunit mu-A isoform 2

    See identical proteins and their annotated locations for NP_997742.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    BX470264, EB766597, EH432280, EH494715
    UniProtKB/Swiss-Prot
    Q6NWK2, Q802V9
    UniProtKB/TrEMBL
    A0A8M2B673, F1RD00
    Related
    ENSDARP00000046586.5, ENSDART00000046587.7
    Conserved Domains (2) summary
    cd09251
    Location:168 → 435
    AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
    cd14836
    Location:1 → 139
    AP2_Mu_N; AP-2 complex subunit mu N-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    9789820..9818673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NWK2.1 GenPept UniProtKB/Swiss-Prot:Q6NWK2

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