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Kmn1 kinetochore Mis12-Ndc80 network component 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32102, updated on 4-Jan-2025

Summary

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Official Symbol
Kmn1provided by FlyBase
Official Full Name
kinetochore Mis12-Ndc80 network component 1provided by FlyBase
Primary source
FLYBASE:FBgn0027259
Locus tag
Dmel_CG1558
See related
AllianceGenome:FB:FBgn0027259
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO03040301.201; CG1558; CT4038; Dmel\CG1558; dmNsl1R; l(1)G0237; nsl1; Nsl1
Summary
Involved in mitotic chromosome movement towards spindle pole; mitotic metaphase chromosome alignment; and regulation of cell cycle. Located in kinetochore. Part of MIS12/MIND type complex and Ndc80 complex. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Kmn1 in Genome Data Viewer
Location:
10C6-10C7; 1-35 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11571383..11572442, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11465416..11466475, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene RNA polymerase II subunit A Neighboring gene antisense RNA:CR44266 Neighboring gene uncharacterized protein Neighboring gene Receptor accessory protein like 1 Neighboring gene uncharacterized protein Neighboring gene enhancer of yellow 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tumor suppressor roles of CENP-E and Nsl1 in Drosophila epithelial tissues. Clemente-Ruiz M, et al. Cell Cycle, 2014. PMID 24626182, Free PMC Article
  2. A transposable element insertion confers xenobiotic resistance in Drosophila. Mateo L, et al. PLoS Genet, 2014 Aug. PMID 25122208, Free PMC Article
  3. Network of protein interactions within the Drosophila inner kinetochore. Richter MM, et al. Open Biol, 2016 Feb. PMID 26911623, Free PMC Article
  4. Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster. Liu Y, et al. Open Biol, 2016 Feb. PMID 26911624, Free PMC Article
  5. Drosophila Mis12 complex acts as a single functional unit essential for anaphase chromosome movement and a robust spindle assembly checkpoint. Venkei Z, et al. Genetics, 2011 Jan. PMID 20980244, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic chromosome movement towards spindle pole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MIS12/MIND type complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Ndc80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
kinetochore Mis12-Ndc80 network component 1
Names
CG1558-PA
CG1558-PB
Kmn1-PA
Kmn1-PB
Nsl1-related protein
l(1)G0237
lethal (1) G0237

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11571383..11572442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132501.3 → NP_572729.1  kinetochore Mis12-Ndc80 network component 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572729.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8Q853, B8Q859, Q9VYX4
    Related
    FBpp0073386

  2. NM_001316625.1 → NP_001303554.1  kinetochore Mis12-Ndc80 network component 1, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    B8Q853, B8Q859, Q9VYX4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VYX4 Q9VYX4

Gene LinkOut

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