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Tnpo3 transportin 3 [ Mus musculus (house mouse) ]

Gene ID: 320938, updated on 27-Nov-2024

Summary

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Official Symbol
Tnpo3provided by MGI
Official Full Name
transportin 3provided by MGI
Primary source
MGI:MGI:1196412
See related
Ensembl:ENSMUSG00000012535 AllianceGenome:MGI:1196412
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trn-SR; mKIAA4133; D6Ertd313e; 5730544L10Rik; C430013M08Rik
Summary
Predicted to enable identical protein binding activity and small GTPase binding activity. Predicted to be involved in protein import into nucleus. Predicted to be located in annulate lamellae and nuclear envelope. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 2. Orthologous to human TNPO3 (transportin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 24.3), placenta adult (RPKM 20.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tnpo3 in Genome Data Viewer
Location:
6 A3.3; 6 12.36 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29540826..29609918, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29540827..29609858, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene sperm microtubule inner protein 1 Neighboring gene kielin/chordin-like protein Neighboring gene predicted gene, 26627 Neighboring gene STARR-positive B cell enhancer ABC_E3647 Neighboring gene STARR-seq mESC enhancer starr_15441 Neighboring gene interferon regulatory factor 5 Neighboring gene STARR-seq mESC enhancer starr_15442 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29559591-29559700 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29559883-29560036 Neighboring gene STARR-seq mESC enhancer starr_15443 Neighboring gene STARR-seq mESC enhancer starr_15447 Neighboring gene STARR-positive B cell enhancer ABC_E6419 Neighboring gene STARR-seq mESC enhancer starr_15449 Neighboring gene predicted gene, 30896 Neighboring gene predicted gene, 38780

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A limited number of B cell lineages generates the heterogeneity of a secondary immune response. Blier PR, et al. J Immunol, 1987 Dec 15. PMID 3500977
  2. Genetic basis for T cell recognition of a major histocompatibility complex class II-restricted neo-self peptide. Cerasoli DM, et al. J Exp Med, 1995 Nov 1. PMID 7595203, Free PMC Article
  3. Clonal diversity, somatic mutation, and immune memory to phosphocholine-keyhole limpet hemocyanin. Stenzel-Poore MP, et al. J Immunol, 1989 Dec 15. PMID 2512351
  4. Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis. Costa R, et al. Mol Cell Biochem, 2021 Apr. PMID 33452620, Free PMC Article
  5. Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling. Bayer M, et al. Genes Dev, 2022 Aug 1. PMID 36167471, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling.
    Title: Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling.
  2. Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis.
    Title: Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4133, MGC90049

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in annulate lamellae ISO
Inferred from Sequence Orthology
more info
  
located_in annulate lamellae ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
transportin-3
Names
transportin-SR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347079.2 → NP_001334008.1  transportin-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC079276
    Consensus CDS
    CCDS85023.1
    UniProtKB/TrEMBL
    Q6DI95
    Related
    ENSMUSP00000110906.2, ENSMUST00000115251.8

  2. NM_001361290.1 → NP_001348219.1  transportin-3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC079276
    UniProtKB/TrEMBL
    Q6DI95
    Conserved Domains (1) summary
    pfam08389
    Location:54 → 182
    Xpo1; Exportin 1-like protein

  3. NM_177296.5 → NP_796270.2  transportin-3 isoform 1

    See identical proteins and their annotated locations for NP_796270.2

    Status: VALIDATED

    Source sequence(s)
    AC079276
    Consensus CDS
    CCDS19963.1
    UniProtKB/Swiss-Prot
    Q6P2B1, Q7TSL6, Q8BKX4, Q8BP42
    UniProtKB/TrEMBL
    Q6DI95
    Related
    ENSMUSP00000012679.9, ENSMUST00000012679.15
    Conserved Domains (2) summary
    smart00913
    Location:33 → 96
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:120 → 248
    Xpo1; Exportin 1-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    29540826..29609918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505121.5 → XP_006505184.1  transportin-3 isoform X3

    UniProtKB/TrEMBL
    Q6DI95
    Conserved Domains (1) summary
    pfam08389
    Location:55 → 182
    Xpo1; Exportin 1-like protein

  2. XM_030255468.2 → XP_030111328.1  transportin-3 isoform X1

    UniProtKB/TrEMBL
    Q6DI95
    Conserved Domains (2) summary
    smart00913
    Location:8 → 62
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:86 → 214
    Xpo1; Exportin 1-like protein

  3. XM_030255469.1 → XP_030111329.1  transportin-3 isoform X2

    UniProtKB/TrEMBL
    Q6DI95
    Conserved Domains (2) summary
    smart00913
    Location:8 → 62
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:86 → 214
    Xpo1; Exportin 1-like protein

  4. XM_030255470.1 → XP_030111330.1  transportin-3 isoform X4

    UniProtKB/TrEMBL
    Q6DI95
    Conserved Domains (1) summary
    pfam08389
    Location:54 → 182
    Xpo1; Exportin 1-like protein

  5. XM_036166242.1 → XP_036022135.1  transportin-3 isoform X3

    UniProtKB/TrEMBL
    Q6DI95
    Conserved Domains (1) summary
    pfam08389
    Location:55 → 182
    Xpo1; Exportin 1-like protein

  6. XM_036166243.1 → XP_036022136.1  transportin-3 isoform X3

    UniProtKB/TrEMBL
    Q6DI95
    Conserved Domains (1) summary
    pfam08389
    Location:55 → 182
    Xpo1; Exportin 1-like protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P2B1.1 GenPept UniProtKB/Swiss-Prot:Q6P2B1

Gene LinkOut

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