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Cyp4g15 Cytochrome P450 4g15 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32093, updated on 9-Dec-2024

Summary

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Official Symbol
Cyp4g15provided by FlyBase
Official Full Name
Cytochrome P450 4g15provided by FlyBase
Primary source
FLYBASE:FBgn0030304
Locus tag
Dmel_CG11715
See related
AllianceGenome:FB:FBgn0030304
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
152658_at; 4g15; CG11715; cyp4g15; CYP4G15; Dmel\CG11715
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; ganglia; larval central nervous system; larval nervous system; and presumptive embryonic/larval central nervous system. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Cyp4g15 in Genome Data Viewer
Location:
10B15-10B15; 1-34 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11477058..11483233)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11371091..11377266)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Heterochromatin protein 5 Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-like activating enzyme 5 Neighboring gene Spase 25-subunit Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insights into unique features of Drosophila CYP4G enzymes. Kefi M, et al. Insect Biochem Mol Biol, 2024 Jan. PMID 38008364
  2. Origin and evolution of the CYP4G subfamily in insects, cytochrome P450 enzymes involved in cuticular hydrocarbon synthesis. Feyereisen R. Mol Phylogenet Evol, 2020 Feb. PMID 31805344
  3. A new cytochrome P450 from Drosophila melanogaster, CYP4G15, expressed in the nervous system. Maïbèche-Coisne M, et al. Biochem Biophys Res Commun, 2000 Jul 14. PMID 10891384
  4. On the genomic location of the exuperantia1 gene in Drosophila miranda: the limits of in situ hybridization experiments. Bachtrog D, et al. Genetics, 2003 Jul. PMID 12871928, Free PMC Article
  5. Systemic and local cues drive neural stem cell niche remodelling during neurogenesis in Drosophila. Spéder P, et al. Elife, 2018 Jan 4. PMID 29299997, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 4g15
Names
CG11715-PA
CG11715-PC
Cyp4g15-PA
Cyp4g15-PC
cytochrome P450
NP_572721.1
NP_727531.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11477058..11483233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167287.2 → NP_727531.2  cytochrome P450 4g15, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727531.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VYY4
    UniProtKB/TrEMBL
    Q8IR88
    Conserved Domains (1) summary
    pfam00067
    Location:47 → 542
    p450; Cytochrome P450

  2. NM_132493.3 → NP_572721.1  cytochrome P450 4g15, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572721.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VYY4
    UniProtKB/TrEMBL
    Q8IR88
    Related
    FBpp0073352
    Conserved Domains (1) summary
    pfam00067
    Location:47 → 542
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IR88 Q8IR88
Q9VYY4.1 Q9VYY4

Gene LinkOut

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