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Wscd2 WSC domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 320916, updated on 27-Nov-2024

Summary

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Official Symbol
Wscd2provided by MGI
Official Full Name
WSC domain containing 2provided by MGI
Primary source
MGI:MGI:2445030
See related
Ensembl:ENSMUSG00000063430 AllianceGenome:MGI:2445030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm450; 4933413A10Rik; C530024P05Rik
Summary
Enables sulfotransferase activity. Located in Golgi membrane. Is expressed in inner ear; skeleton; tarsus; and telencephalon mantle layer. Orthologous to human WSCD2 (WSC domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 22.8), colon adult (RPKM 8.6) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Wscd2 in Genome Data Viewer
Location:
5 F; 5 55.55 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113636976..113727786)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113489110..113589725)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14038 Neighboring gene activator of yeast meiotic promoters 1 Neighboring gene STARR-seq mESC enhancer starr_14039 Neighboring gene STARR-seq mESC enhancer starr_14040 Neighboring gene predicted gene, 30812 Neighboring gene STARR-seq mESC enhancer starr_14042 Neighboring gene predicted gene, 52822 Neighboring gene STARR-seq mESC enhancer starr_14044 Neighboring gene STARR-seq mESC enhancer starr_14048 Neighboring gene STARR-seq mESC enhancer starr_14049 Neighboring gene chemerin chemokine-like receptor 1 Neighboring gene predicted gene 15736 Neighboring gene predicted gene, 52823

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sulfation of sialic acid is ubiquitous and essential for vertebrate development. Ertunc N, et al. Sci Rep, 2022 Jul 21. PMID 35864127, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
sialate:O-sulfotransferase 2
Names
WSC domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177292.3 → NP_796266.2  sialate:O-sulfotransferase 2

    See identical proteins and their annotated locations for NP_796266.2

    Status: VALIDATED

    Source sequence(s)
    BC096526
    Consensus CDS
    CCDS19550.2
    UniProtKB/Swiss-Prot
    D4PHA7, Q69ZZ2, Q8C7Q3
    Related
    ENSMUSP00000092021.4, ENSMUST00000094452.4
    Conserved Domains (2) summary
    smart00321
    Location:134 → 225
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:421 → 513
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    113636976..113727786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320928.2 → XP_017176417.1  sialate:O-sulfotransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    D4PHA7, Q69ZZ2, Q8C7Q3
    Conserved Domains (2) summary
    smart00321
    Location:134 → 225
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:421 → 513
    Sulfotransfer_3; Sulfotransferase family

  2. XM_036165221.1 → XP_036021114.1  sialate:O-sulfotransferase 2 isoform X3

    Conserved Domains (2) summary
    smart00321
    Location:1 → 72
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:163 → 255
    Sulfotransfer_3; Sulfotransferase family

  3. XM_030254582.2 → XP_030110442.1  sialate:O-sulfotransferase 2 isoform X2

    Conserved Domains (3) summary
    smart00321
    Location:34 → 128
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl02568
    Location:1 → 23
    WSC; WSC domain
    cl21551
    Location:219 → 311
    Sulfotransfer_3; Sulfotransferase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4PHA7.1 GenPept UniProtKB/Swiss-Prot:D4PHA7

Gene LinkOut

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