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HP5 Heterochromatin protein 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32090, updated on 4-Jan-2025

Summary

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Official Symbol
HP5provided by FlyBase
Official Full Name
Heterochromatin protein 5provided by FlyBase
Primary source
FLYBASE:FBgn0030301
Locus tag
Dmel_CG1745
See related
AllianceGenome:FB:FBgn0030301
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1745; Dmel\CG1745
Summary
Located in chromocenter and heterochromatin. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See HP5 in Genome Data Viewer
Location:
10B14-10B14; 1-34 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11454786..11459227)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11348819..11353260)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Glutamine synthetase 2 Neighboring gene Ecotropic viral integration site 5 Neighboring gene Sphingosine kinase 1 Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 4g15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phase separation drives heterochromatin domain formation. Strom AR, et al. Nature, 2017 Jul 13. PMID 28636597, Free PMC Article
  2. HP1 controls genomic targeting of four novel heterochromatin proteins in Drosophila. Greil F, et al. EMBO J, 2007 Feb 7. PMID 17255947, Free PMC Article
  3. Functional conservation of the Drosophila hybrid incompatibility gene Lhr. Brideau NJ, et al. BMC Evol Biol, 2011 Mar 2. PMID 21366928, Free PMC Article
  4. Stepwise evolution of essential centromere function in a Drosophila neogene. Ross BD, et al. Science, 2013 Jun 7. PMID 23744945, Free PMC Article
  5. Global chromatin domain organization of the Drosophila genome. de Wit E, et al. PLoS Genet, 2008 Mar 28. PMID 18369463, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
located_in chromocenter IDA
Inferred from Direct Assay
more info
 PubMed 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
heterochromatin protein 5
Names
CG1745-PA
CG1745-PB
CG1745-PC
HP5-PA
HP5-PB
HP5-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11454786..11459227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132490.3 → NP_572718.2  heterochromatin protein 5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572718.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYY7
    Related
    FBpp0073348
    Conserved Domains (1) summary
    PTZ00341
    Location:458 → 745
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional

  2. NM_001272522.1 → NP_001259451.1  heterochromatin protein 5, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259451.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHL2
    Conserved Domains (1) summary
    PLN03237
    Location:66 → 248
    PLN03237; DNA topoisomerase 2; Provisional

  3. NM_206686.3 → NP_996409.1  heterochromatin protein 5, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996409.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960N6
    Conserved Domains (1) summary
    PLN03237
    Location:66 → 248
    PLN03237; DNA topoisomerase 2; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PHL2 M9PHL2
Q960N6 Q960N6
Q9VYY7 Q9VYY7

Gene LinkOut

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