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Tim8 Tim8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32081, updated on 4-Jan-2025

Summary

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Official Symbol
Tim8provided by FlyBase
Official Full Name
Tim8provided by FlyBase
Primary source
FLYBASE:FBgn0027359
Locus tag
Dmel_CG1728
See related
AllianceGenome:FB:FBgn0027359
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:SD06593; CG1728; Dmel\CG1728
Summary
Predicted to enable protein transporter activity. Predicted to be involved in protein insertion into mitochondrial inner membrane. Located in mitochondrion. Is expressed in adult head. Orthologous to human TIMM8B (translocase of inner mitochondrial membrane 8 homolog B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Tim8 in Genome Data Viewer
Location:
10B6-10B6; 1-34 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11368445..11369283)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11262478..11263316)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene PTIP associated 1 Neighboring gene hopscotch Neighboring gene discs large 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systemic Regulation of Host Energy and Oogenesis by Microbiome-Derived Mitochondrial Coenzymes. Gnainsky Y, et al. Cell Rep, 2021 Jan 5. PMID 33406416
  2. Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model. Zhu JY, et al. PLoS One, 2013. PMID 24386261, Free PMC Article
  3. PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane. Gehrke S, et al. Cell Metab, 2015 Jan 6. PMID 25565208, Free PMC Article
  4. [Identification of C(2)M interacting proteins by yeast two-hybrid screening]. Yue SS, et al. Yi Chuan, 2015 Nov. PMID 26582530
  5. Mating-responsive genes in reproductive tissues of female Drosophila melanogaster. Mack PD, et al. Proc Natl Acad Sci U S A, 2006 Jul 5. PMID 16798875, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein insertion into mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mitochondrial intermembrane space protein transporter complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
Tim8
Names
CG1728-PA
CG1728-PB
Tim8-PA
Tim8-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11368445..11369283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298191.1 → NP_001285120.1  Tim8, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285120.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9Y1A3
    UniProtKB/TrEMBL
    X2JB87
    Conserved Domains (1) summary
    pfam02953
    Location:16 → 76
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  2. NM_132485.4 → NP_572713.1  Tim8, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572713.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9Y1A3
    UniProtKB/TrEMBL
    X2JB87
    Related
    FBpp0073338
    Conserved Domains (1) summary
    pfam02953
    Location:16 → 76
    zf-Tim10_DDP; Tim10/DDP family zinc finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y1A3.1 Q9Y1A3
X2JB87 X2JB87

Gene LinkOut

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