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CG44422 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32063, updated on 9-Dec-2024

Summary

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Official Symbol
CG44422provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0265595
Locus tag
Dmel_CG44422
See related
AllianceGenome:FB:FBgn0265595
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11105; CG12625; CG34144; CG42683; Dmel\CG44422; Dm_X:57642
Old locus tag
Dmel_CG11105; Dmel_CG12625; Dmel_CG34144; Dmel_CG42683
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of signal transduction. Is expressed in adult head. Orthologous to human KCNIP1 (potassium voltage-gated channel interacting protein 1) and KCNIP4 (potassium voltage-gated channel interacting protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG44422 in Genome Data Viewer
Location:
10B1-10B2; 1-34 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11219379..11302783, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11113412..11196816, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44765 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 10a Neighboring gene sisterless A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular evolution and population genetic analysis of candidate female reproductive genes in Drosophila. Panhuis TM, et al. Genetics, 2006 Aug. PMID 16783023, Free PMC Article
  2. Stress response, behavior, and development are shaped by transposable element-induced mutations in Drosophila. Rech GE, et al. PLoS Genet, 2019 Feb. PMID 30753202, Free PMC Article
  3. Retroactive, a membrane-anchored extracellular protein related to vertebrate snake neurotoxin-like proteins, is required for cuticle organization in the larva of Drosophila melanogaster. Moussian B, et al. Dev Dyn, 2005 Jul. PMID 15844167
  4. Epi-MEIF: detecting higher order epistatic interactions for complex traits using mixed effect conditional inference forests. Saha S, et al. Nucleic Acids Res, 2022 Oct 28. PMID 36107776, Free PMC Article
  5. Identification of genes expressed during Drosophila melanogaster gastrulation by using subtractive hybridization. González-Agüero M, et al. Gene, 2005 Jan 31. PMID 15716118

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG44422-PA
CG44422-PB
CG44422-PC
CG44422-PD
CG44422-PE
CG44422-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11219379..11302783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272515.2 → NP_001259444.1  uncharacterized protein Dmel_CG44422, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259444.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEA8
    Conserved Domains (2) summary
    COG5126
    Location:254 → 422
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:349 → 421
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. NM_001201649.4 → NP_001188578.1  uncharacterized protein Dmel_CG44422, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188578.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MS47
    Conserved Domains (2) summary
    COG5126
    Location:254 → 419
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:346 → 418
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. NM_167277.2 → NP_727507.2  uncharacterized protein Dmel_CG44422, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727507.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A023GPJ1
    Conserved Domains (2) summary
    COG5126
    Location:181 → 346
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:273 → 345
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. NM_132471.5 → NP_572699.2  uncharacterized protein Dmel_CG44422, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572699.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IR92
    Conserved Domains (2) summary
    COG5126
    Location:254 → 419
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:346 → 418
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  5. NM_001298188.1 → NP_001285117.1  uncharacterized protein Dmel_CG44422, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285117.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JJG0
    Conserved Domains (2) summary
    COG5126
    Location:181 → 346
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:273 → 345
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  6. NM_132472.4 → NP_572700.2  uncharacterized protein Dmel_CG44422, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572700.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZ13
    Conserved Domains (2) summary
    COG5126
    Location:268 → 433
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:360 → 432
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A023GPJ1 A0A023GPJ1
M9MS47 M9MS47
M9PEA8 M9PEA8
Q8IR92 Q8IR92
Q9VZ13 Q9VZ13
X2JJG0 X2JJG0

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