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Dop1a DOP1 leucine zipper like protein A [ Mus musculus (house mouse) ]

Gene ID: 320615, updated on 4-Jan-2025

Summary

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Official Symbol
Dop1aprovided by MGI
Official Full Name
DOP1 leucine zipper like protein Aprovided by MGI
Primary source
MGI:MGI:1289294
See related
Ensembl:ENSMUSG00000034973 AllianceGenome:MGI:1289294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dopey1; C130028L17; D9Ertd809e; B130005I07Rik
Summary
Predicted to be involved in Golgi to endosome transport and protein transport. Predicted to be located in Golgi-associated vesicle. Predicted to be active in endosome and trans-Golgi network. Is expressed in cerebellum; neocortex; and spleen. Orthologous to human DOP1A (DOP1 leucine zipper like protein A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in CNS E18 (RPKM 6.0), CNS E14 (RPKM 5.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Dop1a in Genome Data Viewer
Location:
9 E3.1; 9 46.58 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (86349194..86436683)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (86467141..86555806)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1553 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24831 Neighboring gene STARR-seq mESC enhancer starr_24832 Neighboring gene sorting nexin 4 pseudogene Neighboring gene ubiquitin protein ligase E3D Neighboring gene STARR-positive B cell enhancer ABC_E9332 Neighboring gene STARR-positive B cell enhancer ABC_E10572 Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene malic enzyme 1, NADP(+)-dependent, cytosolic Neighboring gene STARR-seq mESC enhancer starr_24835 Neighboring gene RIKEN cDNA A330041J22 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genome-wide screening and identification of novel proteolytic cleavage targets of caspase-8 and -10 in vitro. Bae S, et al. Int J Mol Med, 2008 Mar. PMID 18288386
  2. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Nakano Y, et al. PLoS Genet, 2012. PMID 23055939, Free PMC Article
  3. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article
  4. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1117, MGC49390

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi to endosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi-associated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein DOP1A; protein dopey-1
Names
dopey family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408204.1 → NP_001395133.1  protein DOP1A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157998
    UniProtKB/Swiss-Prot
    Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8

  2. NM_001408205.1 → NP_001395134.1  protein DOP1A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157998
    UniProtKB/Swiss-Prot
    Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8

  3. NM_177208.4 → NP_796182.2  protein DOP1A isoform 1

    See identical proteins and their annotated locations for NP_796182.2

    Status: VALIDATED

    Source sequence(s)
    AC157998
    Consensus CDS
    CCDS52876.1
    UniProtKB/Swiss-Prot
    Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
    UniProtKB/TrEMBL
    H7BWZ9
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2088 → 2324
    Dopey_N; Dopey, N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    86349194..86436683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511239.4 → XP_006511302.1  protein dopey-1 isoform X7

    UniProtKB/Swiss-Prot
    Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2089 → 2325
    Dopey_N; Dopey, N-terminal

  2. XM_006511240.4 → XP_006511303.1  protein dopey-1 isoform X8

    See identical proteins and their annotated locations for XP_006511303.1

    UniProtKB/Swiss-Prot
    Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
    UniProtKB/TrEMBL
    H7BWZ9
    Related
    ENSMUSP00000140740.2, ENSMUST00000190957.7
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2088 → 2324
    Dopey_N; Dopey, N-terminal

  3. XM_036155068.1 → XP_036010961.1  protein dopey-1 isoform X12

    UniProtKB/Swiss-Prot
    Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2078 → 2314
    Dopey_N; Dopey, N-terminal

  4. XM_030244420.1 → XP_030100280.1  protein dopey-1 isoform X9

    UniProtKB/Swiss-Prot
    Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2080 → 2316
    Dopey_N; Dopey, N-terminal

  5. XM_006511241.4 → XP_006511304.1  protein dopey-1 isoform X11

    UniProtKB/Swiss-Prot
    Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2079 → 2315
    Dopey_N; Dopey, N-terminal

  6. XM_017313433.2 → XP_017168922.1  protein dopey-1 isoform X1

    UniProtKB/Swiss-Prot
    Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2089 → 2325
    Dopey_N; Dopey, N-terminal

  7. XM_006511236.4 → XP_006511299.1  protein dopey-1 isoform X2

    UniProtKB/Swiss-Prot
    Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2088 → 2324
    Dopey_N; Dopey, N-terminal

  8. XM_006511237.4 → XP_006511300.1  protein dopey-1 isoform X4

    UniProtKB/Swiss-Prot
    Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2079 → 2315
    Dopey_N; Dopey, N-terminal

  9. XM_036155066.1 → XP_036010959.1  protein dopey-1 isoform X6

    UniProtKB/Swiss-Prot
    Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2078 → 2314
    Dopey_N; Dopey, N-terminal

  10. XM_017313434.2 → XP_017168923.1  protein dopey-1 isoform X3

    UniProtKB/Swiss-Prot
    Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2080 → 2316
    Dopey_N; Dopey, N-terminal

  11. XM_006511238.4 → XP_006511301.1  protein dopey-1 isoform X5

    UniProtKB/Swiss-Prot
    Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 295
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2079 → 2315
    Dopey_N; Dopey, N-terminal

  12. XM_006511235.4 → XP_006511298.1  protein dopey-1 isoform X1

    UniProtKB/Swiss-Prot
    Q80XM5, Q8BIX5, Q8BIY4, Q8BL99, Q8BLK8
    Conserved Domains (2) summary
    pfam04118
    Location:13 → 297
    Dopey_N; Dopey, N-terminal
    cl04407
    Location:2089 → 2325
    Dopey_N; Dopey, N-terminal

  13. XM_017313435.1 → XP_017168924.1  protein dopey-1 isoform X15

    Conserved Domains (1) summary
    cl04407
    Location:1526 → 1762
    Dopey_N; Dopey, N-terminal

  14. XM_011242758.3 → XP_011241060.1  protein dopey-1 isoform X13

    Conserved Domains (1) summary
    cl04407
    Location:1526 → 1762
    Dopey_N; Dopey, N-terminal

  15. XM_011242759.3 → XP_011241061.1  protein dopey-1 isoform X14

    Conserved Domains (1) summary
    cl04407
    Location:1525 → 1761
    Dopey_N; Dopey, N-terminal

RNA

  1. XR_004935458.1 RNA Sequence

  2. XR_379426.5 RNA Sequence

  3. XR_004935457.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BL99.2 GenPept UniProtKB/Swiss-Prot:Q8BL99

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