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Rnf152 ring finger protein 152 [ Mus musculus (house mouse) ]

Gene ID: 320311, updated on 27-Nov-2024

Summary

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Official Symbol
Rnf152provided by MGI
Official Full Name
ring finger protein 152provided by MGI
Primary source
MGI:MGI:2443787
See related
Ensembl:ENSMUSG00000047496 AllianceGenome:MGI:2443787
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A930029B02Rik
Summary
Predicted to enable small GTPase binding activity and ubiquitin protein ligase activity. Involved in cellular response to amino acid starvation; negative regulation of TORC1 signaling; and positive regulation of autophagy. Predicted to be located in lysosome and organelle membrane. Predicted to be active in lysosomal membrane. Is expressed in forebrain. Orthologous to human RNF152 (ring finger protein 152). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 5.5), whole brain E14.5 (RPKM 4.9) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf152 in Genome Data Viewer
Location:
1 E2.1; 1 49.45 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (105204642..105284665, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (105276917..105356991, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cadherin 20 Neighboring gene STARR-seq mESC enhancer starr_01837 Neighboring gene predicted gene, 53576 Neighboring gene STARR-seq mESC enhancer starr_01838 Neighboring gene STARR-seq mESC enhancer starr_01839 Neighboring gene STARR-seq mESC enhancer starr_01840 Neighboring gene predicted gene, 41925 Neighboring gene predicted gene 29012 Neighboring gene STARR-seq mESC enhancer starr_01841 Neighboring gene predicted gene, 17634 Neighboring gene predicted gene 28403 Neighboring gene predicted gene, 57564

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183. Wu Y, et al. PLoS One, 2018. PMID 29300766, Free PMC Article
  2. RNF152 positively regulates TLR/IL-1R signaling by enhancing MyD88 oligomerization. Xiong MG, et al. EMBO Rep, 2020 Mar 4. PMID 31930677, Free PMC Article
  3. Ubiquitination of Rheb governs growth factor-induced mTORC1 activation. Deng L, et al. Cell Res, 2019 Feb. PMID 30514904, Free PMC Article
  4. The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation. Deng L, et al. Mol Cell, 2015 Jun 4. PMID 25936802
  5. A genomic atlas of mouse hypothalamic development. Shimogori T, et al. Nat Neurosci, 2010 Jun. PMID 20436479, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF152 positively regulates TLR/IL-1R signaling by enhancing MyD88 oligomerization.
    Title: RNF152 positively regulates TLR/IL-1R signaling by enhancing MyD88 oligomerization.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in organelle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF152
Names
RING-type E3 ubiquitin transferase RNF152
NP_001153840.1
NP_848894.1
XP_017176696.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160368.1 → NP_001153840.1  E3 ubiquitin-protein ligase RNF152

    See identical proteins and their annotated locations for NP_001153840.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AC162907, CJ112559
    Consensus CDS
    CCDS15204.1
    UniProtKB/Swiss-Prot
    Q0VF67, Q8BG47
    Related
    ENSMUSP00000128632.2, ENSMUST00000172299.2
    Conserved Domains (1) summary
    cd16548
    Location:11 → 55
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

  2. NM_178779.4 → NP_848894.1  E3 ubiquitin-protein ligase RNF152

    See identical proteins and their annotated locations for NP_848894.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AC162907, AK035832, CJ112559
    Consensus CDS
    CCDS15204.1
    UniProtKB/Swiss-Prot
    Q0VF67, Q8BG47
    Related
    ENSMUSP00000050103.6, ENSMUST00000058688.7
    Conserved Domains (1) summary
    cd16548
    Location:11 → 55
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    105204642..105284665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321207.3 → XP_017176696.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    UniProtKB/Swiss-Prot
    Q0VF67, Q8BG47
    Conserved Domains (1) summary
    cd16548
    Location:11 → 55
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG47.1 GenPept UniProtKB/Swiss-Prot:Q8BG47

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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