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feo fascetto [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32015, updated on 4-Jan-2025

Summary

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Official Symbol
feoprovided by FlyBase
Official Full Name
fascettoprovided by FlyBase
Primary source
FLYBASE:FBgn0030241
Locus tag
Dmel_CG11207
See related
AllianceGenome:FB:FBgn0030241
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11207; Dmel\CG11207; EA86; Feo; Feo1; l(1)9Fe; l(1)BP1; PRC1; Q54
Summary
Predicted to enable microtubule binding activity. Involved in mitotic spindle organization. Located in cytosol and spindle midzone. Is expressed in several structures, including CNS glial cell; anterior endoderm; central brain primordium; embryonic/larval midgut primordium; and ganglia. Orthologous to human PRC1 (protein regulator of cytokinesis 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See feo in Genome Data Viewer
Location:
9F5-9F5; 1-33 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10852446..10854869, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10746479..10748902, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene 6-phosphogluconolactonase Neighboring gene uncharacterized protein Neighboring gene sister of feo Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Astral microtubule cross-linking safeguards uniform nuclear distribution in the Drosophila syncytium. Deshpande O, et al. J Cell Biol, 2022 Jan 3. PMID 34766978, Free PMC Article
  2. Recruitment of Polo kinase to the spindle midzone during cytokinesis requires the Feo/Klp3A complex. D'Avino PP, et al. PLoS One, 2007 Jun 27. PMID 17593971, Free PMC Article
  3. Live Imaging and Analysis of Meiotic Cytokinesis in Drosophila Testes. Kunduri G, et al. Bio Protoc, 2024 Jan 20. PMID 38268980, Free PMC Article
  4. [Characteristics of inserted mutations obtained in the P-M hybrid dysgenesis system in the 9F12-10A7 region of the Drosophila melanogaster X-chromosome]. Pokholkova GV, et al. Genetika, 1989 Oct. PMID 2559870
  5. Neuronal necrosis is regulated by a conserved chromatin-modifying cascade. Liu K, et al. Proc Natl Acad Sci U S A, 2014 Sep 23. PMID 25201987, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRC1 binding to polycomb response elements is not strictly dependent on PRC2 and H3K27 methylation.
    Title: Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements.
  2. Feo may control organization, stability, and motor composition of antiparallel interpolar microtubules at midzone, thereby facilitating kinesin-5-driven sliding filament mechanism underlying proper anaphase B spindle elongation and chromosome segregation
    Title: The microtubule cross-linker Feo controls the midzone stability, motor composition, and elongation of the anaphase B spindle in Drosophila embryos.
  3. Data show that Sticky (Sti), tile ring component Citron kinase (CIT-K) interacts directly with two kinesins, Nebbish and Pavarotti and that in turn these kinesins interact with each other and with another central spindle protein, Fascetto.
    Title: Citron kinase controls a molecular network required for midbody formation in cytokinesis.
  4. Feo interacts with the plus ends of central spindle microtubules (MTs) so as to maintain their precise interdigitation during anaphase-telophase MT elongation and antiparallel sliding.
    Title: Feo, the Drosophila homolog of PRC1, is required for central-spindle formation and cytokinesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fascetto
Names
CG11207-PA
fasecetto
feo-PA
lethal(1)9Fe

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    10852446..10854869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132430.3 → NP_572658.2  fascetto [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572658.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZ62
    Related
    FBpp0073266
    Conserved Domains (1) summary
    pfam03999
    Location:39 → 613
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T9H6 Q8T9H6
Q95SC3 Q95SC3
Q9VZ62 Q9VZ62

Gene LinkOut

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