U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tns3 tensin 3 [ Mus musculus (house mouse) ]

Gene ID: 319939, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Tns3provided by MGI
Official Full Name
tensin 3provided by MGI
Primary source
MGI:MGI:2443012
See related
Ensembl:ENSMUSG00000020422 AllianceGenome:MGI:2443012
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TEM6; Tens1; F830010I22Rik
Summary
Enables guanyl-nucleotide exchange factor adaptor activity. Involved in positive regulation of guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including bone resorption; podosome assembly; and regulation of small GTPase mediated signal transduction. Located in podosome. Is expressed in several structures, including craniocervical region bone; foot mesenchyme; reproductive system; spleen primordium; and tail. Orthologous to human TNS3 (tensin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 31.3), ovary adult (RPKM 22.7) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tns3 in Genome Data Viewer
Location:
11 A1; 11 4.99 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (8381652..8614758, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (8431652..8664758, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA aspartic acid 10 (anticodon GTC) Neighboring gene predicted gene, 27393 Neighboring gene STARR-seq mESC enhancer starr_28503 Neighboring gene STARR-seq mESC enhancer starr_28504 Neighboring gene STARR-seq mESC enhancer starr_28506 Neighboring gene STARR-seq mESC enhancer starr_28507 Neighboring gene STARR-seq mESC enhancer starr_28508 Neighboring gene STARR-seq mESC enhancer starr_28509 Neighboring gene STARR-seq mESC enhancer starr_28511 Neighboring gene STARR-seq mESC enhancer starr_28512 Neighboring gene STARR-seq mESC enhancer starr_28518 Neighboring gene STARR-seq mESC enhancer starr_28520 Neighboring gene STARR-seq mESC enhancer starr_28524 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:8501700-8501809 Neighboring gene STARR-seq mESC enhancer starr_28532 Neighboring gene STARR-seq mESC enhancer starr_28533 Neighboring gene STARR-seq mESC enhancer starr_28537 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:8600745-8600973 Neighboring gene STARR-seq mESC enhancer starr_28543 Neighboring gene STARR-seq mESC enhancer starr_28544 Neighboring gene STARR-seq mESC enhancer starr_28546 Neighboring gene predicted gene, 36772 Neighboring gene general transcription factor II A, 1 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination. Juilland M, et al. Proc Natl Acad Sci U S A, 2023 Dec 26. PMID 38109544, Free PMC Article
  2. Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation. Merour E, et al. Elife, 2022 Oct 10. PMID 36214451, Free PMC Article
  3. Tensins are versatile regulators of Rho GTPase signalling and cell adhesion. Blangy A. Biol Cell, 2017 Mar. PMID 27748980
  4. Inactivation of tensin3 in mice results in growth retardation and postnatal lethality. Chiang MK, et al. Dev Biol, 2005 Mar 15. PMID 15733665
  5. Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity. Touaitahuata H, et al. J Cell Sci, 2016 Sep 15. PMID 27505886

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination.
    Title: Identification of Tensin-3 as a MALT1 substrate that controls B cell adhesion and lymphoma dissemination.
  2. Dock5 and tensin 3 cooperate for osteoclast activity, to ensure the correct organization of podosomes.
    Title: Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity.
  3. Tensin3 is a versatile regulator of DOCK5 signaling and cell adhesion. (Review)
    Title: Tensins are versatile regulators of Rho GTPase signalling and cell adhesion.
  4. Tns3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis.
    Title: The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis.
  5. Results indicate that tensin3 is essential for normal development and functions of the small intestine, lung, and bone [tensin3].
    Title: Inactivation of tensin3 in mice results in growth retardation and postnatal lethality.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within bone resorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lung alveolus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within podosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Rac protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of Rac protein signal transduction IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in podosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
tensin-3
Names
tensin-like SH2 domain containing 1
tensin-like SH2 domain-containing protein 1
tumor endothelial marker 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083587.1 → NP_001077056.1  tensin-3

    See identical proteins and their annotated locations for NP_001077056.1

    Status: VALIDATED

    Source sequence(s)
    AK052680, AK158101, AL603845, AL662881, AW259174, BU056564, BY154424
    Consensus CDS
    CCDS36109.1
    UniProtKB/Swiss-Prot
    Q3TZ54, Q5SSZ5, Q8BJA7
    UniProtKB/TrEMBL
    A0A5F8MPF2
    Related
    ENSMUSP00000020695.7, ENSMUST00000020695.13
    Conserved Domains (6) summary
    cd09927
    Location:1163 → 1279
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:794 → 1073
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:532 → 964
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:1303 → 1434
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:8 → 166
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:173 → 299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    8381652..8614758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156761.1 → XP_036012654.1  tensin-3 isoform X2

    UniProtKB/TrEMBL
    A0A5F8MPF2
    Conserved Domains (7) summary
    cd09927
    Location:1312 → 1428
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:943 → 1222
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:681 → 1113
    PHA03307; transcriptional regulator ICP4; Provisional
    cd14561
    Location:157 → 315
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:322 → 448
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd20889
    Location:69 → 124
    C1_TNS3_v; protein kinase C conserved region 1 (C1 domain) found in tensin-3 (TNS3) variant and similar proteins
    cl17171
    Location:1452 → 1511
    PH-like; Pleckstrin homology-like domain

  2. XM_036156762.1 → XP_036012655.1  tensin-3 isoform X3

    UniProtKB/Swiss-Prot
    Q3TZ54, Q5SSZ5, Q8BJA7
    UniProtKB/TrEMBL
    A0A5F8MPF2
    Conserved Domains (6) summary
    cd09927
    Location:1163 → 1279
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:794 → 1073
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:532 → 964
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:1303 → 1434
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:8 → 166
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:173 → 299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

  3. XM_006514741.3 → XP_006514804.1  tensin-3 isoform X3

    See identical proteins and their annotated locations for XP_006514804.1

    UniProtKB/Swiss-Prot
    Q3TZ54, Q5SSZ5, Q8BJA7
    UniProtKB/TrEMBL
    A0A5F8MPF2
    Conserved Domains (6) summary
    cd09927
    Location:1163 → 1279
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:794 → 1073
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:532 → 964
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:1303 → 1434
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:8 → 166
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:173 → 299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

  4. XM_036156764.1 → XP_036012657.1  tensin-3 isoform X3

    UniProtKB/Swiss-Prot
    Q3TZ54, Q5SSZ5, Q8BJA7
    UniProtKB/TrEMBL
    A0A5F8MPF2
    Conserved Domains (6) summary
    cd09927
    Location:1163 → 1279
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:794 → 1073
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:532 → 964
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:1303 → 1434
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:8 → 166
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:173 → 299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

  5. XM_011243728.4 → XP_011242030.1  tensin-3 isoform X3

    See identical proteins and their annotated locations for XP_011242030.1

    UniProtKB/Swiss-Prot
    Q3TZ54, Q5SSZ5, Q8BJA7
    UniProtKB/TrEMBL
    A0A5F8MPF2
    Conserved Domains (6) summary
    cd09927
    Location:1163 → 1279
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:794 → 1073
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:532 → 964
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:1303 → 1434
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:8 → 166
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:173 → 299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

  6. XM_011243727.3 → XP_011242029.1  tensin-3 isoform X1

    UniProtKB/TrEMBL
    A0A5F8MP98, A0A5F8MPF2
    Related
    ENSMUSP00000158873.2, ENSMUST00000239091.2
    Conserved Domains (7) summary
    cd09927
    Location:1276 → 1392
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:907 → 1186
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:645 → 1077
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00029
    Location:35 → 81
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:1416 → 1547
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:121 → 279
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:286 → 412
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

  7. XM_030246087.1 → XP_030101947.1  tensin-3 isoform X3

    UniProtKB/Swiss-Prot
    Q3TZ54, Q5SSZ5, Q8BJA7
    UniProtKB/TrEMBL
    A0A5F8MPF2
    Conserved Domains (6) summary
    cd09927
    Location:1163 → 1279
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:794 → 1073
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:532 → 964
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:1303 → 1434
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:8 → 166
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:173 → 299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

  8. XM_036156763.1 → XP_036012656.1  tensin-3 isoform X3

    UniProtKB/Swiss-Prot
    Q3TZ54, Q5SSZ5, Q8BJA7
    UniProtKB/TrEMBL
    A0A5F8MPF2
    Conserved Domains (6) summary
    cd09927
    Location:1163 → 1279
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:794 → 1073
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:532 → 964
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:1303 → 1434
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:8 → 166
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:173 → 299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

  9. XM_006514740.4 → XP_006514803.2  tensin-3 isoform X3

    UniProtKB/Swiss-Prot
    Q3TZ54, Q5SSZ5, Q8BJA7
    UniProtKB/TrEMBL
    A0A5F8MPF2
    Conserved Domains (6) summary
    cd09927
    Location:1163 → 1279
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:794 → 1073
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:532 → 964
    PHA03307; transcriptional regulator ICP4; Provisional
    cd01213
    Location:1303 → 1434
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    cd14561
    Location:8 → 166
    PTP_tensin-3; protein tyrosine phosphatase-like domain of tensin-3
    pfam10409
    Location:173 → 299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

  10. XM_006514743.5 → XP_006514806.1  tensin-3 isoform X4

    Conserved Domains (3) summary
    cd09927
    Location:790 → 906
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:421 → 700
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:930 → 1061
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

RNA

  1. XR_380972.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SSZ5.1 GenPept UniProtKB/Swiss-Prot:Q5SSZ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous