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CG2887 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31978, updated on 4-Jan-2025

Summary

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Official Symbol
CG2887provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030207
Locus tag
Dmel_CG2887
See related
AllianceGenome:FB:FBgn0030207
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG2887
Summary
Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be active in cytosol. Orthologous to human DNAJB5 (DnaJ heat shock protein family (Hsp40) member B5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG2887 in Genome Data Viewer
Location:
9D1-9D1; 1-32 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10477260..10478493, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10371293..10372526, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Neb-cGP Neighboring gene no circadian temperature entrainment Neighboring gene uncharacterized protein Neighboring gene Protein phosphatase 4 regulatory subunit 2-related protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A dual role for the dREAM/MMB complex in the regulation of differentiation-specific E2F/RB target genes. Lee H, et al. Mol Cell Biol, 2012 Jun. PMID 22451490, Free PMC Article
  2. A role for the chaperone Hsp70 in the regulation of border cell migration in the Drosophila ovary. Cobreros L, et al. Mech Dev, 2008 Nov-Dec. PMID 18718532
  3. A rapidly evolving MYB-related protein causes species isolation in Drosophila. Barbash DA, et al. Proc Natl Acad Sci U S A, 2003 Apr 29. PMID 12695567, Free PMC Article
  4. Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110. Kuo Y, et al. Cell Death Dis, 2013 Oct 3. PMID 24091676, Free PMC Article
  5. Drosophila RB proteins repress differentiation-specific genes via two different mechanisms. Lee H, et al. Mol Cell Biol, 2010 May. PMID 20176807, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG2887-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    10477260..10478493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132405.3 → NP_572633.1  uncharacterized protein Dmel_CG2887 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572633.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W2U5
    Related
    FBpp0071393
    Conserved Domains (3) summary
    cd10747
    Location:163 → 326
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:1 → 331
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:4 → 65
    DnaJ; DnaJ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W2U5 Q9W2U5

Gene LinkOut

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