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nocte no circadian temperature entrainment [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31976, updated on 4-Jan-2025

Summary

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Official Symbol
nocteprovided by FlyBase
Official Full Name
no circadian temperature entrainmentprovided by FlyBase
Primary source
FLYBASE:FBgn0261710
Locus tag
Dmel_CG17255
See related
AllianceGenome:FB:FBgn0261710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17255; Dmel\CG17255
Summary
Enables mRNA 5'-UTR binding activity. Involved in entrainment of circadian clock; temperature compensation of the circadian clock; and translation reinitiation. Is active in cytosol. Is expressed in several structures, including adult chordotonal organ; chordotonal neurons; larval internal muscle motor neurons; longitudinal vein; and organism subdivision. Orthologous to human PRRC2C (proline rich coiled-coil 2C). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See nocte in Genome Data Viewer
Location:
9C5-9D1; 1-32 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10461865..10474675, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10355898..10368708, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Neb-cGP Neighboring gene Odorant receptor 9a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Protein phosphatase 4 regulatory subunit 2-related protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. nocte Is Required for Integrating Light and Temperature Inputs in Circadian Clock Neurons of Drosophila. Chen C, et al. Curr Biol, 2018 May 21. PMID 29754901
  2. Dpr10 and Nocte are required for Drosophila motor axon pathfinding. Lobb-Rabe M, et al. Neural Dev, 2022 Oct 21. PMID 36271407, Free PMC Article
  3. A mechanosensory pathway to the Drosophila circadian clock. Simoni A, et al. Science, 2014 Jan 31. PMID 24482478
  4. Circadian clock neurons constantly monitor environmental temperature to set sleep timing. Yadlapalli S, et al. Nature, 2018 Mar 1. PMID 29466329
  5. Heating and cooling the Drosophila melanogaster clock. Maguire SE, et al. Curr Opin Insect Sci, 2015 Feb 1. PMID 26120562, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNA-binding protein Nocte regulates Drosophila development by promoting translation reinitiation on mRNAs with long upstream open reading frames.
    Title: RNA-binding protein Nocte regulates Drosophila development by promoting translation reinitiation on mRNAs with long upstream open reading frames.
  2. A temperature input pathway from peripheral sensory organs, which depends on the gene nocte, targets specific subsets of these clock neurons to synchronize molecular and behavioral rhythms to temperature cycles. Strikingly, while nocte1 mutant flies synchronize normally to light-dark cycles at constant temperatures, the combined presence of light-dark and temperature cycles inhibits synchronization.
    Title: nocte Is Required for Integrating Light and Temperature Inputs in Circadian Clock Neurons of Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mRNA 5'-UTR binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in entrainment of circadian clock IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in temperature compensation of the circadian clock IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation reinitiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
no circadian temperature entrainment
Names
CG17255-PA
CG17255-PB
CG17255-PC
CG17255-PD
nocte-PA
nocte-PB
nocte-PC
nocte-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    10461865..10474675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272480.1 → NP_001259409.1  no circadian temperature entrainment, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259409.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PE74
    Conserved Domains (1) summary
    pfam07001
    Location:1 → 155
    BAT2_N; BAT2 N-terminus

  2. NM_167231.5 → NP_727425.3  no circadian temperature entrainment, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727425.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W2U7
    Conserved Domains (1) summary
    pfam07001
    Location:1 → 155
    BAT2_N; BAT2 N-terminus

  3. NM_001258685.2 → NP_001245614.1  no circadian temperature entrainment, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245614.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W2U7
    Conserved Domains (1) summary
    pfam07001
    Location:1 → 155
    BAT2_N; BAT2 N-terminus

  4. NM_132403.5 → NP_572631.3  no circadian temperature entrainment, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572631.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W2U7
    Conserved Domains (1) summary
    pfam07001
    Location:1 → 155
    BAT2_N; BAT2 N-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PE74 M9PE74
Q8MQI1 Q8MQI1
Q9W2U7 Q9W2U7

Gene LinkOut

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