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Idgf4 Imaginal disc growth factor 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31926, updated on 9-Dec-2024

Summary

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Official Symbol
Idgf4provided by FlyBase
Official Full Name
Imaginal disc growth factor 4provided by FlyBase
Primary source
FLYBASE:FBgn0026415
Locus tag
Dmel_CG1780
See related
AllianceGenome:FB:FBgn0026415
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1780; Dmel\CG1780; DmIDGF4; IDGF; IDGF-4; idgf4; IDGF4; IGDF4
Summary
Enables imaginal disc growth factor receptor binding activity. Involved in several processes, including chitin-based cuticle development; ecdysis, chitin-based cuticle; and wound healing. Located in extracellular region. Is expressed in several structures, including adult head; epithelium; germline cell; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIT1 (chitinase 1); CHI3L1 (chitinase 3 like 1); and CHI3L2 (chitinase 3 like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Idgf4 in Genome Data Viewer
Location:
9A3-9A3; 1-30 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9927973..9930948, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9822006..9824981, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CO2 exposure drives a rapid pH response in live adult Drosophila. Zimmerman SG, et al. PLoS One, 2024. PMID 38625910, Free PMC Article
  2. Crystal structure of imaginal disc growth factor-2. A member of a new family of growth-promoting glycoproteins from Drosophila melanogaster. Varela PF, et al. J Biol Chem, 2002 Apr 12. PMID 11821393
  3. A new family of growth factors produced by the fat body and active on Drosophila imaginal disc cells. Kawamura K, et al. Development, 1999 Jan. PMID 9847235
  4. Imaginal disk growth factors are Drosophila chitinase-like proteins with roles in morphogenesis and CO2 response. Sustar AE, et al. Genetics, 2023 Feb 9. PMID 36576887, Free PMC Article
  5. Expansion of Imaginal Disc Growth Factor Gene Family in Diptera Reflects the Evolution of Novel Functions. Zurovcova M, et al. Insects, 2019 Oct 20. PMID 31635152, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c9928201-9928138 mobile_element_type = transposon:INE-1{}5275

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables imaginal disc growth factor receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ecdysis, chitin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region HDA PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
imaginal disc growth factor 4
Names
CG1780-PA
CG1780-PB
CG1780-PC
Idgf4-PA
Idgf4-PB
Idgf4-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9927973..9930948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298139.1 → NP_001285068.1  imaginal disc growth factor 4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285068.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V476, O96667, Q9W303
    UniProtKB/TrEMBL
    X2JEB6
    Conserved Domains (2) summary
    cd02873
    Location:26 → 442
    GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
    smart00636
    Location:27 → 420
    Glyco_18; Glyco_18 domain

  2. NM_078546.4 → NP_511101.2  imaginal disc growth factor 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511101.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V476, O96667, Q9W303
    UniProtKB/TrEMBL
    X2JEB6
    Related
    FBpp0071328
    Conserved Domains (2) summary
    cd02873
    Location:26 → 442
    GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
    smart00636
    Location:27 → 420
    Glyco_18; Glyco_18 domain

  3. NM_167207.3 → NP_727374.1  imaginal disc growth factor 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727374.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V476, O96667, Q9W303
    UniProtKB/TrEMBL
    X2JEB6
    Related
    FBpp0071329
    Conserved Domains (2) summary
    cd02873
    Location:26 → 442
    GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
    smart00636
    Location:27 → 420
    Glyco_18; Glyco_18 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W303.1 Q9W303
X2JEB6 X2JEB6

Gene LinkOut

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