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Lst8 Lst8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31903, updated on 4-Jan-2025

Summary

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Official Symbol
Lst8provided by FlyBase
Official Full Name
Lst8provided by FlyBase
Primary source
FLYBASE:FBgn0264691
Locus tag
Dmel_CG3004
See related
AllianceGenome:FB:FBgn0264691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3004; dGbetaL; dLST8; Dmel\CG3004; Gbl; lst8; LST8
Summary
Involved in several processes, including TORC2 signaling; positive regulation of cell size; and positive regulation of signal transduction. Part of TORC2 complex. Is expressed in adult head. Orthologous to human MLST8 (MTOR associated protein, LST8 homolog). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Lst8 in Genome Data Viewer
Location:
8F1-8F1; 1-29 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9604154..9605969, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9498187..9500002, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45542 Neighboring gene long non-coding RNA:CR45543 Neighboring gene Golgi-localized, gamma-adaptin ear containing, ARF binding protein Neighboring gene Lysyl-tRNA synthetase Neighboring gene Hecw ubiquitin protein ligase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionarily conserved regulation of TOR signalling. Takahara T, et al. J Biochem, 2013 Jul. PMID 23698095
  2. Target of Rapamycin Complex 2 regulates cell growth via Myc in Drosophila. Kuo Y, et al. Sci Rep, 2015 May 22. PMID 25999153, Free PMC Article
  3. GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila. Frappaolo A, et al. Cell Death Dis, 2022 Nov 27. PMID 36435842, Free PMC Article
  4. Are invertebrates relevant models in ageing research? Focus on the effects of rapamycin on TOR. Erdogan CS, et al. Mech Ageing Dev, 2016 Jan. PMID 26763146
  5. Loss of miR-34 in Drosophila dysregulates protein translation and protein turnover in the aging brain. Srinivasan AR, et al. Aging Cell, 2022 Mar. PMID 35166006, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TOR signaling IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in TORC2 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by transcription factor localization IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in protein localization to nucleus IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
NOT part_of TORC1 complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TORC2 complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Lst8
Names
CG3004-PA
Lst8-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9604154..9605969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132344.4 → NP_572572.1  Lst8 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572572.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95RK5, Q9W328
    UniProtKB/TrEMBL
    B4F5L6
    Related
    FBpp0071303
    Conserved Domains (3) summary
    COG2319
    Location:3 → 306
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:8 → 284
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:41 → 78
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W328.2 Q9W328

Gene LinkOut

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