Tsen2 tRNA splicing endonuclease subunit 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tsen2provided by FlyBase
Official Full Name: tRNA splicing endonuclease subunit 2provided by FlyBase
Primary source: FLYBASE:FBgn0051812
Locus tag: Dmel_CG31812
See related: AllianceGenome:FB:FBgn0051812
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG31812; Dmel\CG31812; TSEN2
Summary: Predicted to enable tRNA-intron endonuclease activity. Involved in tRNA processing. Predicted to be part of tRNA-intron endonuclease complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2B. Orthologous to human TSEN2 (tRNA splicing endonuclease subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (16729777..16731199)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (16729777..16731199)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

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Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables tRNA-intron endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA-intron endonuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA splicing, via endonucleolytic cleavage and ligation	IEA Inferred from Electronic Annotation more info
involved_in tRNA-type intron splice site recognition and cleavage	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of tRNA-intron endonuclease complex	IBA Inferred from Biological aspect of Ancestor more info

NP_723994.2

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The following sections contain reference sequences that belong to a specific genome build. Explain