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Bsg Basigin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318841, updated on 9-Dec-2024

Summary

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Official Symbol
Bsgprovided by FlyBase
Official Full Name
Basiginprovided by FlyBase
Primary source
FLYBASE:FBgn0261822
Locus tag
Dmel_CG31605
See related
AllianceGenome:FB:FBgn0261822
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
135/10; basigin; BcDNA:GH21853; bsg; BSG; CG31605; Dmel\CG31605; gel; l(2)06243; l(2)k06338; l(2)k09030; l(2)k13638; l(2)k14308; l(2)SH1217; l(2)SH2 1217; ms(2)08318; NP6293
Summary
Predicted to enable cell-cell adhesion mediator activity. Involved in several processes, including endoplasmic reticulum localization; photoreceptor cell morphogenesis; and sarcomere organization. Located in cytoskeleton of presynaptic active zone. Is expressed in several structures, including CNS surface glial cell; embryonic/larval midgut primordium; enterocyte of middle adult midgut epithelium; epithelium; and synaptic neuropil domain. Orthologous to several human genes including BSG (basigin (Ok blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Bsg in Genome Data Viewer
Location:
28E3-28E6; 2-30 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8083420..8116531)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8083420..8116531)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene TBP-related factor Neighboring gene Macroglobulin complement-related Neighboring gene antisense RNA:CR45257 Neighboring gene monensin sensitivity 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutational analysis of Drosophila basigin function in the visual system. Munro M, et al. Gene, 2010 Jan 1. PMID 19782733, Free PMC Article
  2. The origin and evolution of Basigin(BSG) gene: A comparative genomic and phylogenetic analysis. Zhu X, et al. Dev Comp Immunol, 2017 Jul. PMID 28223252
  3. Basigin/EMMPRIN/CD147 mediates neuron-glia interactions in the optic lamina of Drosophila. Curtin KD, et al. Glia, 2007 Nov 15. PMID 17729283
  4. Sphingolipids regulate neuromuscular synapse structure and function in Drosophila. West RJH, et al. J Comp Neurol, 2018 Sep 1. PMID 29761896, Free PMC Article
  5. DLin-7 is required in postsynaptic lamina neurons to prevent light-induced photoreceptor degeneration in Drosophila. Soukup SF, et al. Curr Biol, 2013 Jul 22. PMID 23850283

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Basigin Associates with Integrin in Order to Regulate Perineurial Glia and Drosophila Nervous System Morphology.
    Title: Basigin Associates with Integrin in Order to Regulate Perineurial Glia and Drosophila Nervous System Morphology.
  2. results suggest that the highly conserved transmembrane domain and the extracellular domains are crucial for basigin function in the visual system while the short intracellular tail may not play a role in these functions
    Title: Mutational analysis of Drosophila basigin function in the visual system.
  3. Basigin expression in photoreceptor neurons is required for normal structure and placement of glia cells
    Title: Basigin/EMMPRIN/CD147 mediates neuron-glia interactions in the optic lamina of Drosophila.
  4. Basigin promotes cytoskeletal rearrangements and the formation of lamellipodia in cultured insect cells
    Title: Basigin (EMMPRIN/CD147) interacts with integrin to affect cellular architecture.
  5. Bsg has a role regulating synaptic compartmentalization and strength, and coordinating plasma membrane and cortical organization.
    Title: The Ig cell adhesion molecule Basigin controls compartmentalization and vesicle release at Drosophila melanogaster synapses.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendrite self-avoidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleus localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in photoreceptor cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton of presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynaptic active zone IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
basigin
Names
Bsg-PA
Bsg-PB
Bsg-PC
Bsg-PD
Bsg-PE
Bsg-PF
Bsg-PG
Bsg-PH
Bsg-PI
Bsg-PJ
CG31605-PA
CG31605-PB
CG31605-PC
CG31605-PD
CG31605-PE
CG31605-PF
CG31605-PG
CG31605-PH
CG31605-PI
CG31605-PJ
D-basigin
gelded
lethal (2) SH1217

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8083420..8116531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164785.2 → NP_723341.1  basigin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723341.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPG9
    Related
    FBpp0079190
    Conserved Domains (3) summary
    smart00410
    Location:125 → 208
    IG_like; Immunoglobulin like
    pfam00047
    Location:124 → 199
    ig; Immunoglobulin domain
    cl11960
    Location:46 → 105
    Ig; Immunoglobulin domain

  2. NM_164784.2 → NP_723340.1  basigin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723340.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPG9
    Related
    FBpp0079191
    Conserved Domains (3) summary
    smart00410
    Location:125 → 208
    IG_like; Immunoglobulin like
    pfam00047
    Location:124 → 199
    ig; Immunoglobulin domain
    cl11960
    Location:46 → 105
    Ig; Immunoglobulin domain

  3. NM_164782.2 → NP_723338.1  basigin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723338.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPG9
    Related
    FBpp0079189
    Conserved Domains (3) summary
    smart00410
    Location:125 → 208
    IG_like; Immunoglobulin like
    pfam00047
    Location:124 → 199
    ig; Immunoglobulin domain
    cl11960
    Location:46 → 105
    Ig; Immunoglobulin domain

  4. NM_164783.2 → NP_723339.1  basigin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723339.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPG9
    Related
    FBpp0079188
    Conserved Domains (3) summary
    smart00410
    Location:125 → 208
    IG_like; Immunoglobulin like
    pfam00047
    Location:124 → 199
    ig; Immunoglobulin domain
    cl11960
    Location:46 → 105
    Ig; Immunoglobulin domain

  5. NM_164790.3 → NP_723346.2  basigin, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723346.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTJ7
    Conserved Domains (3) summary
    cd00096
    Location:512 → 575
    Ig; Immunoglobulin domain
    smart00410
    Location:500 → 583
    IG_like; Immunoglobulin like
    cl11960
    Location:423 → 497
    Ig; Immunoglobulin domain

  6. NM_164787.2 → NP_723343.1  basigin, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723343.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPG9
    Related
    FBpp0079193
    Conserved Domains (3) summary
    smart00410
    Location:125 → 208
    IG_like; Immunoglobulin like
    pfam00047
    Location:124 → 199
    ig; Immunoglobulin domain
    cl11960
    Location:46 → 105
    Ig; Immunoglobulin domain

  7. NM_001273295.1 → NP_001260224.1  basigin, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260224.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCW5
    Conserved Domains (3) summary
    smart00410
    Location:125 → 208
    IG_like; Immunoglobulin like
    pfam00047
    Location:124 → 199
    ig; Immunoglobulin domain
    cl11960
    Location:46 → 105
    Ig; Immunoglobulin domain

  8. NM_164788.2 → NP_723344.1  basigin, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723344.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPG9
    Related
    FBpp0079194
    Conserved Domains (3) summary
    smart00410
    Location:125 → 208
    IG_like; Immunoglobulin like
    pfam00047
    Location:124 → 199
    ig; Immunoglobulin domain
    cl11960
    Location:46 → 105
    Ig; Immunoglobulin domain

  9. NM_164786.2 → NP_723342.1  basigin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723342.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPG9
    Related
    FBpp0079192
    Conserved Domains (3) summary
    smart00410
    Location:125 → 208
    IG_like; Immunoglobulin like
    pfam00047
    Location:124 → 199
    ig; Immunoglobulin domain
    cl11960
    Location:46 → 105
    Ig; Immunoglobulin domain

  10. NM_164789.3 → NP_723345.1  basigin, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723345.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPG9
    Related
    FBpp0079195
    Conserved Domains (3) summary
    smart00410
    Location:125 → 208
    IG_like; Immunoglobulin like
    pfam00047
    Location:124 → 199
    ig; Immunoglobulin domain
    cl11960
    Location:46 → 105
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCW5 M9PCW5
Q7KTJ7 Q7KTJ7
Q8IPG9 Q8IPG9
Q961I4 Q961I4

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