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mxc multi sex combs [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31869, updated on 4-Jan-2025

Summary

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Official Symbol
mxcprovided by FlyBase
Official Full Name
multi sex combsprovided by FlyBase
Primary source
FLYBASE:FBgn0260789
Locus tag
Dmel_CG12124
See related
AllianceGenome:FB:FBgn0260789
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12058; CG12124; Dmel\CG12124; dNPAT; l(1)mbn; MPM-2; mpm2; MPM2; Mxc; MXC; NPAT
Old locus tag
Dmel_CG12058
Summary
Involved in hemocyte differentiation and hemocyte proliferation. Located in histone locus body. Is expressed in gonad; larval ventral nerve cord; and organism. Used to study hematologic cancer and leukemia. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See mxc in Genome Data Viewer
Location:
8D2-8D2; 1-27 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9236801..9243467, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9130834..9137500, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 8a Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 8a Neighboring gene mir-4916 stem loop Neighboring gene La related protein 7 Neighboring gene almondex Neighboring gene Downstream of raf1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ultrastructure and Cytochemistry of the Cell-types in the Tumorous Hematopoietic Organs and the Hemolymph of the Mutant Lethal (1) Malignant Blood Neoplasm (l(1)mbn) of Drosophila Melanogaster: (drosophila/mutant blood cells/ultrastructure/cytochemistry). Shrestha R, et al. Dev Growth Differ, 1982. PMID 37281385
  2. Sequence reliance of the Drosophila context-dependent transcription factor CLAMP. Hodkinson LJ, et al. Genetics, 2024 Jul 8. PMID 38775472,
  3. Functional dissection of Drosophila melanogaster SUUR protein influence on H3K27me3 profile. Posukh OV, et al. Epigenetics Chromatin, 2017 Dec 1. PMID 29191233, Free PMC Article
  4. Persistent replicative stress alters polycomb phenotypes and tissue homeostasis in Drosophila melanogaster. Landais S, et al. Cell Rep, 2014 May 8. PMID 24746823, Free PMC Article
  5. A region of SLBP outside the mRNA-processing domain is essential for deposition of histone mRNA into the Drosophila egg. Potter-Birriel JM, et al. J Cell Sci, 2021 Feb 11. PMID 33408246, Free PMC Article

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Enhancement of leukemia-like phenotypes in Drosophila mxc mutant larvae due to activation of the RAS-MAP kinase cascade possibly via down-regulation of DE-cadherin.
    Title: Enhancement of leukemia-like phenotypes in Drosophila mxc mutant larvae due to activation of the RAS-MAP kinase cascade possibly via down-regulation of DE-cadherin.
  2. The Drosophila abnormal chromosome segregation leading to chromosomal instability (CIN) development results from a loss of chromosome integrity caused by diminished canonical histone levels in mxc mutants.
    Title: Mutations in mxc Tumor-Suppressor Gene Induce Chromosome Instability in Drosophila Male Meiosis.
  3. Multiple domains of the Mxc protein promote histone locus body assembly in order to concentrate factors required for histone mRNA biosynthesis.
    Title: Distinct self-interaction domains promote Multi Sex Combs accumulation in and formation of the Drosophila histone locus body.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in hemocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hemocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hemopoiesis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in histone locus body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in histone locus body IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
multi sex combs
Names
CG12124-PA
CG12124-PB
lethal(1)malignant blood neoplasm
multiple sex combs
mxc-PA
mxc-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9236801..9243467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132320.3 → NP_572548.1  multi sex combs, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572548.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NP21, Q9W363
    Related
    FBpp0071267
    Conserved Domains (1) summary
    PTZ00108
    Location:1414 → 1643
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  2. NM_001298114.1 → NP_001285043.1  multi sex combs, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285043.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NP21, Q9W363
    Conserved Domains (1) summary
    PTZ00108
    Location:1414 → 1643
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W363 Q9W363

Gene LinkOut

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